You are cordially invited to join the Center for Biomolecular Structure Lecture Series ………..
Erik Debler Thomas Jefferson University WEDNESDAY, January 24, 13:30 (EST) "Hybrid methods to investigate the mechanism of Dot1 histone-modifying enzymes in kinetoplastid parasites" Register in advance for this meeting: https://bnl.zoomgov.com/meeting/register/vJItcu2grTotGGdsWXVwtDa4OIkqHcJgvpA Time conversion Link: https://www.worldtimebuddy.com/<https://urldefense.com/v3/__https://gcc02.safelinks.protection.outlook.com/?url=https*3A*2F*2Fwww.worldtimebuddy.com*2F&data=05*7C01*7Cgenoa.blankenship*40pnnl.gov*7C67ffe754733240e42d3e08da641ba4bc*7Cd6faa5f90ae240338c0130048a38deeb*7C0*7C0*7C637932367171794987*7CUnknown*7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0*3D*7C3000*7C*7C*7C&sdata=aSe2IUSomjge9ZW6zXdQ81fPzxpg8eawtRkoiOEJdXM*3D&reserved=0__;JSUlJSUlJSUlJSUlJSUlJSUlJSU!!P4SdNyxKAPE!Fd5kIAbibocFpkUaEbpqZZGm8tw-xiqb5oC4sfOklv6Kbbf-T3RvUobMSLrzyXNbfNVT9vMxJGuY1RsSqbc6MjpIABre1Q$> Abstract: Kinetoplastid parasites are medically important eukaryotes that are responsible for severe neglected tropical diseases including sleeping sickness caused by Trypanosoma brucei. Kinetoplastids have diverged early on in evolution from the metazoan and fungal lineages and have developed distinct mechanisms in gene expression and other molecular processes, which are not only interesting from a mechanistic point of view, but which also have the potential to being exploited for anti-parasitic therapy. Based on a multidisciplinary approach including x-ray crystallography, x-ray footprinting, and mass spectrometry, I will present a mechanism of histone H3 lysine K76 methylation by T. brucei DOT1 enzymes distinct from that of human and yeast homologs, providing insight into the evolution, regulation, and function of kinetoplastid DOT1 methyltransferases. ================== Vivian Stojanoff, PhD Education, Training, Outreach User Program p 1(631) 344 8375 e nsls.lifescien...@gmail.com<mailto:nsls.lifescien...@gmail.com> w https://www.bnl.gov/ps/lifesciences/<https://www.bnl.gov/ps/lsbr/> Address: Center for Biomolecular Structure National Synchrotron Light Source II Building 745 Brookhaven National Laboratory Upton NY 11973 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
