Hi, “… Liv[ing] Crystallography” implies leveraging dynamics through time-resolved studies… But, competing for beamtime at synchrotrons and XFELs can restrict access to those systems that pass PRP scrutiny and likely have multi-method preliminary data from crystalline samples/slurries. However, many enzyme systems are not amenable to techniques that readily yield individual rate constants across a reaction coordinate. Nevertheless, they could be very well-suited to time-resolved structural analysis with serial MX methods and appropriate reaction initiation strategies. How might beamlines and/or facilities coordinate various activities and/or applications to promote dynamic structural biology studies as broadly as possible?
AMO ~ ~ ~ ~ ~ Allen M. Orville, Ph.D. Wellcome Investigator and Royal Society Wolfson Fellow Principal Scientist, XFEL Hub at Diamond Light Source Harwell Science and Innovation Campus Didcot, Oxfordshire OX11 0DE United Kingdom Phone: +44 (0) 1235 567505 Mobile: +44 (0) 7471 026061 email: allen.orvi...@diamond.ac.uk AMO site: https://www.diamond.ac.uk/Instruments/Mx/XFEL-Hub/Staff/Orville.html XFEL-Hub site: https://www.diamond.ac.uk/Instruments/Mx/XFEL-Hub.html From: CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK> on behalf of Nicholas Pearce <00008ea5c90b8e5a-dmarc-requ...@jiscmail.ac.uk> Date: Tuesday, 2 January 2024 at 10:56 To: CCP4BB@JISCMAIL.AC.UK <CCP4BB@JISCMAIL.AC.UK> Subject: [ccp4bb] Input from the community for panel session: Crystallography is Dead! Long Live Crystallography! You don't often get email from 00008ea5c90b8e5a-dmarc-requ...@jiscmail.ac.uk. Learn why this is important<https://aka.ms/LearnAboutSenderIdentification> Hello, and happy new year! Tomorrow evening, we will have a panel discussion at the CCP4 study weekend about the future of crystallography, called “Crystallography is Dead. Long Live Crystallography!” [https://en.wikipedia.org/wiki/The_king_is_dead,_long_live_the_king]. Whether you’re attending the CCP4SW or not, we want to hear from the community about your thoughts on the subject (see the blurb below), so that we can discuss things the community is most interested in! if you have a few minutes, please do fill in the form (all questions are optional): https://forms.office.com/e/3K5qSMNpYh. Thanks, and looking forward to seeing some of you very soon! Your friendly neighbourhood scientific organisation team, Nicholas Pearce, Helen Ginn, and Clemens Vonrhein Blurb: In this session, we will discuss the current state and the future of crystallographic experiments in the context of structural biology: · what are the unconfronted problems that the field still faces? · what problems are now essentially solved? · where should future method development be focussed? · what challenges are emerging from new experimental developments? · do new experiments provide new perspectives on old problems? Inevitably, this will include discussion of whether these challenges are likely to be addressed by the application of recent advances in AI, and, with the continued developments in cryoEM, what is crystallography's role as a part of the structural biologist's toolbox? Panel Chair: Elspeth Garman Panel Members: Dave Brown, Arwen Pearson, Ashwin Chari Please submit questions for consideration during the panel discussion using the form below! and we look forward to seeing you on 3rd Jan! Some of the questions are asked mischievously - you are welcome to have some fun with your answers! All questions are optional! https://forms.office.com/e/3K5qSMNpYh ________________________________ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 -- This e-mail and any attachments may contain confidential, copyright and or privileged material, and are for the use of the intended addressee only. If you are not the intended addressee or an authorised recipient of the addressee please notify us of receipt by returning the e-mail and do not use, copy, retain, distribute or disclose the information in or attached to the e-mail. Any opinions expressed within this e-mail are those of the individual and not necessarily of Diamond Light Source Ltd. Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments are free from viruses and we cannot accept liability for any damage which you may sustain as a result of software viruses which may be transmitted in or with the message. Diamond Light Source Limited (company no. 4375679). Registered in England and Wales with its registered office at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
