The Baker group has also reported substantial progress in all atom predictions
Krishna et al.,
Generalized Biomolecular Modeling and Design with RoseTTAFold All-Atom
bioRxiv 2023.10.09.561603
doi: 10.1101/2023.10.09.561603
https://www.biorxiv.org/content/10.1101/2023.10.09.561603v1.full
Regards,
Mitch
Quoting Tom Terwilliger <0000b6116340b489-dmarc-requ...@jiscmail.ac.uk>:
Hi Roberto,
Thanks for the link to the DeepMind site! I hadn't seen that and now I
read it and the paper that they link to. It looks to me as though they are
making significant progress on ligands, dna, rna, but that the program is
not yet available, so I don't think it can be tested yet!
All the best,
Tom T
On Fri, Dec 1, 2023 at 5:19 AM Roberto Steiner <roberto.stei...@kcl.ac.uk>
wrote:
Great paper indeed!
However quite significant progress seems to have been achieved with
ligands as well (and not only)…
https://urldefense.com/v3/__https://deepmind.google/discover/blog/a-glimpse-of-the-next-generation-of-alphafold/__;!!BuQPrrmRaQ!mWTLfJ8Bjj3YYdp1ZCa8HXyjF-1lq1emf12VPcusoqMN5sh4Eajgq-3UOcaWAERlTNpVWXSdqVPUzhyjIYzPrkIn0P-gtdIjb9GM9FxbyWs$
Has anyone in the community put this to the test?
Best wishes
Roberto
*Roberto A Steiner*
https://urldefense.com/v3/__http://www.steinerlab.org__;!!BuQPrrmRaQ!mWTLfJ8Bjj3YYdp1ZCa8HXyjF-1lq1emf12VPcusoqMN5sh4Eajgq-3UOcaWAERlTNpVWXSdqVPUzhyjIYzPrkIn0P-gtdIjb9GMxbA8Qgg$
https://urldefense.com/v3/__https://twitter.com/steiner_lab__;!!BuQPrrmRaQ!mWTLfJ8Bjj3YYdp1ZCa8HXyjF-1lq1emf12VPcusoqMN5sh4Eajgq-3UOcaWAERlTNpVWXSdqVPUzhyjIYzPrkIn0P-gtdIjb9GMZmS2rX0$
roberto.stei...@kcl.ac.uk
Randall Centre for Cell and Molecular Biophysics
Faculty of Life Sciences and Medicine
King's College London
Room 3.10A
New Hunt's House, Guy's Campus
SE1 1UL, London, UK
Phone 0044 20 78488216
Fax 0044 20 78486435
roberto.stei...@unipd.it
Dipartimento di Scienze Biomediche
Università degli Studi di Padova
Viale G. Colombo 3
35131 Padova, Italia
Telefono 0039 049 8276409
*Responses to emails are not expected outside of your normal working
hours.*
On 30 Nov 2023, at 22:35, Tom Terwilliger <
0000b6116340b489-dmarc-requ...@jiscmail.ac.uk> wrote:
You don't often get email from
0000b6116340b489-dmarc-requ...@jiscmail.ac.uk. Learn why this is important
<https://aka.ms/LearnAboutSenderIdentification>
Hi Structural biologist colleagues!
Our article that helps you make the case that the experiment is still very
much needed is now out:
https://www.nature.com/articles/s41592-023-02087-4
"AlphaFold predictions are valuable hypotheses and accelerate but do not
replace experimental structure determination." Nature Methods (2023)
Also, here is a video on the Phenix Tutorials YouTube channel that
describes this analysis:
https://urldefense.com/v3/__https://www.youtube.com/watch?v=ugMPYdPo8Bc__;!!BuQPrrmRaQ!mWTLfJ8Bjj3YYdp1ZCa8HXyjF-1lq1emf12VPcusoqMN5sh4Eajgq-3UOcaWAERlTNpVWXSdqVPUzhyjIYzPrkIn0P-gtdIjb9GMqp4wPP4$
(I hope you will be happy to see that you and your structural biology
colleagues get the credit for making AlphaFold possible at 2:35 in the
introduction of this video! Keep up the fantastic structural biology work!)
All the best,
Tom T
--
Thomas C Terwilliger
Laboratory Fellow, Los Alamos National Laboratory
Senior Scientist, New Mexico Consortium
100 Entrada Dr, Los Alamos, NM 87544
Email: tterwilli...@newmexicoconsortium.org
Tel: 505-431-0010
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100 Entrada Dr, Los Alamos, NM 87544
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