Hi Devbrat, here are a couple of other things to try:
- When screening crystals use rastering to find regions of the sample where 
multiple lattices may be less problematic. If multiple lattices are observed, 
often regions on the crystal(s) close to the edge will not be as affected by 
twinning/multiple lattices. Also try using fine slicing if you are not already.
- Try using AlphaFold to generate a model for the MR template.
All the best,John
    On Wednesday, November 15, 2023 at 06:10:06 AM CST, Phil Evans 
<p...@mrc-lmb.cam.ac.uk> wrote:  
 
 Is the space group really P2? P21 is MUCH more common
Phil

> On 14 Nov 2023, at 15:55, Devbrat Kumar <devformed...@gmail.com> wrote:
> 
> sed data were integrated with the data reduction tool AIMLESS in the CCP4i2 
> suite.

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