Please join us live or register to view on-demand: Machine Learning Approach to Cellular Cryo-Tomography November 01, 2023 03:00 PM (London) 11:00 AM (New York) 08:00 AM (San Francisco)
Speakers: Ellen Zhong, Princeton Abhay Kotecha, Thermo Fisher Scientific https://events.bitesizebio.com/machine-learning-approach-to/join What do dynamic protein complexes look like inside the cell? Advances in cryo-electron tomography (cryo-ET) offer unprecedented insights into dynamic protein complexes within cells. This webinar introduces cryoDRGN-ET, an open-source machine learning approach for reconstructing and visualizing biomolecular structures from in situ cryo-ET subtomograms. To demonstrate its effectiveness to capture diverse states in composition and conformation, it was applied to a dataset of 120000 subtomograms of S. cerevisiae ribosomes, revealing the distribution of functional states during translation elongation in situ. In this webinar you will learn: - How cryo-tomography can visualize cellular architecture in three dimensions at nanometer resolution - Overview of computational processing of 3D tomograms that can further resolve structures at sub-nanometer resolution - How cryoDRGN-ET avoids extensive classification and masking Leah Lavery, PhD Sr. Marketing Development Manager Materials & Structural Analysis Division Thermo Fisher Scientific 6055 Sunol Boulevard | Pleasanton, CA 94566 USA Mobile: +1 (503) 523-7344 leah.lav...@thermofisher.com<mailto:leah.lav...@thermofisher.com> | www.thermofisher.com/electron-microscopy<https://www.thermofisher.com/us/en/home/electron-microscopy/life-sciences.html> WORLDWIDE CONFIDENTIALITY NOTE: Dissemination, distribution or copying of this e-mail or the information herein by anyone other than the intended recipient, or an employee or agent of a system responsible for delivering the message to the intended recipient, is prohibited. If you are not the intended recipient, please inform the sender and delete all copies. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
