Dear All,
We are recruiting a highly motivated a highly motivated*Post-Doctoral
Scientist *to join**our teamat EMBL Grenoble, interested in the
molecular mechanisms underlying the architecture and assembly of muscle
sarcomeres, particular Z-discs. We use a multidisciplinary approach to
tackle complex biological problems by combining complementary structural
biology techniques, computational modelling, and other biochemical and
biophysical methods. The main focus of this position will be integrative
structural studies of reconstituted assemblies.
*Your role***
•Taking up and leading a challenging structural biology project
•Designing and performing experimental procedures
•Analysing and interpreting experimental data
•Taking part in regular group meetings, unit seminars and international
conferences
•Staying up to date with the literature and the latest methodological
developments relevant to the project
You will embark on an exciting journey to decipher the structures of
selected reconstituted complexes and macromolecular condensates using an
integrative structural biology approach, which encompasses molecular
biophysics characterisation, combined with small angles X-ray
scattering, macromolecular crystallography, and cryo-electron
microscopy/tomography, depending on their size and dynamics. As a team
member, you will play a crucial role in uncovering the detailed
biophysical and structural principles that regulate complex assembly.
Joining collaborative efforts, you will contribute to the generation of
a 4D multiscale integrative molecular model.
*You have*
* PhD degree in molecular biology or a related field
·Extensive experience in molecular cloning, expression, and purification
of protein complexes is essential.
·Prior knowledge of crystallography and/or single-particle electron
microscopy is needed.
·Track record of writing papers as evidenced by publications or
submitted manuscripts.
* Independence and ability to solve problems
* Good time management and pro-active attitude
* Excellent communication skills and ability to work in a team
*You might also have*
·Previous experience in complementary structural biology methods (e.g.
SAXS), molecular and cell biophysics approaches and cell culture will be
considered an advantage.
·Experience with cryo-electron tomography.
·Experience with working in multidisciplinary research teams.
**
*Why join us*
The European Molecular Biology Laboratory (EMBL) is one of the
highest-ranked scientific research organisations in the worldaimed to
explore the secrets of life. The Headquarters Laboratory is located in
Heidelberg (Germany) and further Units are situated in Grenoble
(France), Hamburg (Germany), Hinxton (UK), Rome (Italy) and Barcelona
(Spain).
EMBL Grenoble shares the European Photon and Neutron Science (EPN)
Campus with the European Synchrotron Radiation Facility (ESRF), the
/Institut Laue Langevin /(ILL) and the French national /Institut de
Biologie Structurale /(IBS), whose complementary and integrated
facilities provide a vibrant environment for structural biologists.
EMBL Grenoble enables access to state-of-the-art structural biology
technologies with the local EM facility equipped with the T12 screening
microscope and a 200kV Glacios microscope with Falcon4i/SelectrisX
detector. Additionally, we have a regular access to five 300kV
microscopes located locally at ESRF and at EMBL Heidelberg. Other
facilities include high-performance computing cluster, dedicated GPU
workstations for data processing and deep learning applications, ESRF
synchrotron X-ray beamlines, high-field NMR at the IBS as well as
mammalian and insect cell facilities, biophysical platform, confocal
microscopy and high-throughput crystallization facilities.
EMBL is an inclusive, equal opportunity employer offering attractive
conditions and benefits appropriate to an international research
organisation with a very collegial and family friendly working
environment. The remuneration package comprises a competitive salary, a
comprehensive pension scheme, medical, educational and other social
benefits, as well as financial support for relocation and installation,
including your family.
*What else you need to know*
We are Europe’s flagship research laboratory for the life sciences – an
intergovernmental organisation performing scientific research in
disciplines including molecular biology, physics, chemistry and computer
science. We are an international, innovative and interdisciplinary
laboratory with more than 1900 employees from many nations, operating
across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge,
Hamburg, Grenoble and Rome.
Our mission is to offer vital services in training scientists, students
and visitors at all levels; to develop new instruments and methods in
the life sciences and actively engage in technology transfer activities,
and to integrate European life science research.
The contract is for 3 years.
Please compile an application package containing:
•Letter of interest
•Your CV
•Contact details for threereferences
Please apply online at: https://www.embl.org/jobs/position/GR00217
Deadline: 19.11.2023
Shortlisting Deadline: 2 weeks after deadline
Interviews: 2-3 weeks after deadline
Prospective start date: ASAP
Contract Duration: 3 years
--
-----
*Kristina Djinovic Carugo*
Head of EMBL Grenoble
European Molecular Biology Laboratory (EMBL) Grenoble
71 Avenue des Martyrs
38000 Grenoble, France
Email:kristina.djino...@embl.org
Website: http://www.embl.fr
Tel:+33 4 76 20 7876; Secretary +33 4 76 20 7123
Mobile: +33 6 60 72 71 61
EMBL_logo
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