Dear CCP4 Community, Our lab at Stanford (https://rogala.stanford.edu) has open postdoctoral positions for structural biologists and protein biochemists. We are a fairly young lab, and we are looking for driven candidates with a start-up mentality and a deep interest in deciphering protein mechanisms. Please feel free to spread the word to your about-to-graduate PhD students who might be looking for their next career step!
Please see the official ad on the Stanford postdoc website here <https://postdocs.stanford.edu/prospective/opportunities/open-postdoctoral-position-faculty-mentor-kacper-rogala>, and a short blurb below — describing what the lab is about. Potential candidates, please write a few lines about yourself — about your previous research experience, and what you liked about our lab that got you interested! Please include your CV and contact details to three references. Many thanks and best wishes, Kacper KACPER ROGALA, D.PHIL. *Assistant Professor* *–––––––––––––––––––––––––––––––-* Department of Structural Biology <https://med.stanford.edu/structuralbio.html> Department of Chemical and Systems Biology <https://chemsysbio.stanford.edu/> Stanford Cancer Institute <http://med.stanford.edu/cancer.html> Stanford University School of Medicine Biomedical Innovations Building 240 Pasteur Drive, 4700 | Palo Alto, CA, 94304 https://rogala.stanford.edu We are a team of structural and chemical biologists fascinated by how cells control their metabolism in response to nutrients. How are nutrients recognized by their protein sensors? How is their transport across cellular and intracellular membranes regulated? And, how is nutrient sensing integrated with other chemical signals, such as hormones, to determine cellular decisions, especially the decision: to grow or not to grow? We are aiming to answer these fundamental questions at the level of ångstroms, nanometers, and micrometers — with cryo-EM, X-ray crystallography, and a full range of other techniques. Many proteins in nutrient signaling pathways are deregulated in cancer, and in parallel to the mechanistic structural work, we are also developing targeted chemical probes to modulate activity of these proteins in cells and organisms. *We work on large soluble signaling complexes and membrane protein transporters.* Our latest papers on this topic are: - Valenstein and Rogala et al. (2022) Structure of the nutrient-sensing hub GATOR2. Nature, 607(7919):610-616. PMID: 35831510 <https://pubmed.ncbi.nlm.nih.gov/35831510/>. - Rogala et al. (2019) Structural basis for the docking of mTORC1 on the lysosomal surface. Science, 366(6464):468-475. PMID: 31601708 <https://pubmed.ncbi.nlm.nih.gov/31601708>. - Shen and Rogala et al. (2019) Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex. Cell, 179(6):1319-1329.e8. PMID: 31704029 <https://pubmed.ncbi.nlm.nih.gov/31704029>. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
