Bard (draft 2 of 3) Sure, here is a critical review report rejecting a scientific paper reporting that the 1.0 angstrom crystal structure shows that psiX is a trimethylating enzyme:
Title: Critical Review Report: PsiX is not a Trimethylating Enzyme Author: Bard Date: 2023-05-12 Introduction The paper "Crystal Structure of PsiX Reveals a Trimethylating Enzyme" by [Authors] (2023) reports the 1.0 angstrom crystal structure of the enzyme PsiX. The authors conclude that PsiX is a trimethylating enzyme that catalyzes the methylation of the C5 position of guanine. Critique There are several major flaws in the paper that call into question the authors' conclusions. First, the authors' interpretation of the crystal structure is based on a number of assumptions that are not supported by the data. For example, the authors assume that the residues that are close to the C5 position of guanine are involved in the methylation reaction. However, there is no evidence to support this assumption. The residues could be involved in other aspects of the enzyme's activity, such as substrate binding or catalysis. Second, the authors' experiments do not provide any direct evidence that PsiX is a trimethylating enzyme. The authors show that PsiX can methylate guanine in vitro. However, they do not show that PsiX is the only enzyme that can methylate guanine in vivo. It is possible that there are other enzymes that can methylate guanine, and that PsiX is not involved in this reaction. Third, the authors' experiments do not provide any information about the mechanism of the methylation reaction. The authors suggest that PsiX uses a SAM-dependent mechanism to methylate guanine. However, they do not provide any evidence to support this suggestion. It is possible that PsiX uses a different mechanism to methylate guanine. Conclusion The paper by [Authors] (2023) does not provide convincing evidence that PsiX is a trimethylating enzyme. The authors' interpretation of the crystal structure is based on a number of assumptions that are not supported by the data. The authors' experiments do not provide any direct evidence that PsiX is a trimethylating enzyme, and they do not provide any information about the mechanism of the methylation reaction. Based on these criticisms, I recommend that the paper be rejected. thumb_upthumb_down upload Google it more_vert -- David On Fri, 12 May 2023 at 16:50, Cowan, Richard H. (Dr.) <rc...@leicester.ac.uk> wrote: > The underlying model that drives Bing is ChatGPT, so perhaps not a > surprise they produce the same output. Maybe giving Bard or Llama the same > prompt might give different results. > > > > Thanks, > > > > *Richard Cowan* > > *Research Fellow* > > > > Leicester Institute of Structural and Chemical Biology > > Department of Molecular and Cell Biology > > University of Leicester | University Road | Leicester | LE1 7RH | UK > > > > *t:* +44 (0)116 229 7077 > > *e:* rc...@leicester.ac.uk <x...@leicester.ac.uk> > *w:* www.le.ac.uk > [image: > vxWQrlsJKAEloASUgBJQAkpg+xJQQbp9+eroSkAJKAEloASUgBJQAg0QUEHaACB9rASUgBJQAkpACSgBJbB9Cagg3b58dXQloASUgBJQAkpACSiBBgioIG0AkD5WAkpACSgBJaAElIAS2L4EVJBuX746uhJQAkpACSgBJaAElEADBFSQNgBIHysBJaAElIASUAJKQAlsXwIqSLcvXx1dCSgBJaAElIASUAJKoAECKkgbAKSPlYASUAJKQAkoASWgBLYvARWk25evjq4ElIASUAJKQAkoASWgBJSAElACSkAJKAEloASUwI5M4P8AZ4taSLRHMpYAAAAASUVORK5CYII=] > > > Follow us on Twitter <https://twitter.com/uniofleicester> or visit our > Facebook <http://www.facebook.com/uniofleicester> page > > > > > > > > *From: *CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK> on behalf of Bruno > KLAHOLZ <klah...@igbmc.fr> > *Date: *Friday, 12 May 2023 at 16:36 > *To: *CCP4BB@JISCMAIL.AC.UK <CCP4BB@JISCMAIL.AC.UK> > *Subject: *Re: [ccp4bb] About the A in AI > > ****CAUTION:**** This email was sent from an *EXTERNAL* source. Think > before clicking links or opening attachments. > > > > indeed, probably they are using the same databases and features. > > Same happens in translations btw. > > > > Cheers, > > > > Bruno > > > > > > *From:* CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK> *On Behalf Of *Ian > Tickle > *Sent:* 12 May 2023 17:33 > *To:* CCP4BB@JISCMAIL.AC.UK > *Subject:* Re: [ccp4bb] About the A in AI > > > > > > Hi Bernhard > > > > Methinks there's some cribbing going on between Bing and ChatGPT - not > only deja-vu but the reviews are identical word for word! How is that > possible? > > > > Cheers > > > > -- Ian > > > > > > On Fri, 12 May 2023 at 16:15, Bernhard Rupp <hofkristall...@gmail.com> > wrote: > > For those who concern themselves with such matters, here the responses > from Bing and ChatGPT to the prompt: > > > > “Please write a critical review report rejecting a scientific paper > reporting that the 1.0 angstrom crystal structure shows that psiX is a > trimethylating enzyme” > > > > Enjoy the frightening reading and then we can chat (LOL) about the creepy > feeling of déjà-vu you might experience…. > > > > https://www.dropbox.com/s/2fo9u3d11dk8n0o/Bing.docx?dl=0 > > https://www.dropbox.com/s/9gr34grpcrf7yk7/ChatGPT.docx?dl=0 > > > > Cheers, BR > > > > ----------------------------------------------------------------- > Bernhard Rupp > > k.k. Hofkristallamt > > 001 (925) 209-7429 > +43 (676) 571-0536 > b...@ruppweb.org > hofkristall...@gmail.com > *http://www.hofkristallamt.org/ <http://www.hofkristallamt.org/>* > > ----------------------------------------------------------------- > Hope is not a strategy - hope is a mistake. > > ----------------------------------------------------------------- > > > > > ------------------------------ > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > > > ------------------------------ > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > > > ------------------------------ > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > > ------------------------------ > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 > ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
