Dear ccp4 community, We are recruiting for a postdoctoral position at Diamond to work on developing room temperature fragment screening as a tool in drug discovery. This is part of a major international project funded by Horizon-Europe (see link below) so has a lot of opportunity for international collaboration and/or travel. The overall idea of the project is to investigate the binding fragments under non-cryogenic conditions and to optimise methodology and pipelines to achieve this in a time and sample efficient manner.
I'd be grateful if this could be brought to the attention of candidates who may be interested in joining athe team. https://vacancies.diamond.ac.uk/vacancy/pdra-vmxi-room-temperature-fragment-screening-infratech-503820.html Thanks, Mike About the Role We now have an excellent opportunity for a Post-Doctoral Research Associate (PDRA) to conduct world-leading research aimed at developing room temperature fragment screening into a key tool for the development of new therapies. This role is part of a major EU funded international project called 'Fragment-Screen', involving six leading research centres across Europe together with seven industrial partners including IBM and Astex Pharmaceuticals. Working together we will make advances in the application of X-ray crystallography, cryo-EM and NMR for fragment screening as well as applying advanced computational approaches to hit identification and development. The role therefore offers an excellent opportunity to be part of an international, interdisciplinary research team. Details on the overall project are available here: https://instruct-eric.org/news/fragment-screen-a-new-european-project-coordinated-by-instruct-eric/ The Versatile Macromolecular Crystallography in-situ (VMXi) beamline at Diamond is dedicated to room temperature data collection from macromolecular crystals. It is an entirely automated facility for characterisation of, and data collection directly from, crystallisation experiments in situ. Working with the beamline team you will conduct experiments to determine and implement the most effective pipelines to carry out fragment screens at room temperature. You will investigate the differences between fragment binding under the usual cryogenic conditions and at room temperature. This work will be within an overall part of the project concerned with X-ray diffraction including other researchers at Diamond and the ESRF, France. The PDRA will be responsible for: * Carrying out experiments to fulfil the aims of the research proposal. This may vary from protein crystallisation, carrying out fragment campaigns and X-ray crystallographic data analysis to pipeline optimisation. * Managing the day-to-day running of a research project. * Identifying research objectives. * Attending scientific meetings including consortium meetings and presenting your research. * Leading in the analysis and authoring of scientific results in international peer-reviewed journals. This role is an 18-month fix term contract from appointment. About You You should hold a degree in science, with a PhD relevant to the research area. You should demonstrate knowledge or experience of: * Macromolecular crystallography * Protein crystallisation * Crystallographic data processing software * Fragment screening / drug design methods (desirable) * Synchrotron radiation-based research (desirable) You will demonstrate good interpersonal, communication and presentational skills, with the ability to interact effectively with staff and facility users/collaborators at all levels. Benefits Diamond offers an exceptional benefits package to support staff in achieving a positive work/life balance. This includes 25 days annual leave plus 13 days of statutory and company holidays and 2 annual volunteering days, along with flexible working hours and an excellent pension scheme. Staff also have access to a range of amenities on site including a nursery, cafes, a restaurant and sports and leisure facilities. A relocation allowance may also be available where applicable. To Apply Please use the online application process to apply and tell us why you believe you are suitable for this role. The initial closing date for applications is 12th March 2023, however applications will be reviewed and interviewed on an ongoing basis until this vacancy is filled. PDRA - Room temperature fragment screening, beamline VMXi Harwell Science and Innovation Campus, Oxfordshire Salary £33,963 - £39,955 per annum Full time / Flexible hours considered 18 months fixed term Ref: 10931 -- This e-mail and any attachments may contain confidential, copyright and or privileged material, and are for the use of the intended addressee only. If you are not the intended addressee or an authorised recipient of the addressee please notify us of receipt by returning the e-mail and do not use, copy, retain, distribute or disclose the information in or attached to the e-mail. Any opinions expressed within this e-mail are those of the individual and not necessarily of Diamond Light Source Ltd. Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments are free from viruses and we cannot accept liability for any damage which you may sustain as a result of software viruses which may be transmitted in or with the message. Diamond Light Source Limited (company no. 4375679). Registered in England and Wales with its registered office at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
