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Amir Khan Associate Professor Trinity College Dublin WEDNESDAY, JANUARY 18, 13:30 (EST) "PPM1H phosphatase specificity for Rab GTPases" Register in advance for this meeting: https://bnl.zoomgov.com/meeting/register/vJIsceugqDwoGHSNUX28x5ZhdmleK_hkPVw Time conversion Link: https://www.worldtimebuddy.com/<https://urldefense.com/v3/__https:/gcc02.safelinks.protection.outlook.com/?url=https*3A*2F*2Fwww.worldtimebuddy.com*2F&data=05*7C01*7Cgenoa.blankenship*40pnnl.gov*7C67ffe754733240e42d3e08da641ba4bc*7Cd6faa5f90ae240338c0130048a38deeb*7C0*7C0*7C637932367171794987*7CUnknown*7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0*3D*7C3000*7C*7C*7C&sdata=aSe2IUSomjge9ZW6zXdQ81fPzxpg8eawtRkoiOEJdXM*3D&reserved=0__;JSUlJSUlJSUlJSUlJSUlJSUlJSU!!P4SdNyxKAPE!Fd5kIAbibocFpkUaEbpqZZGm8tw-xiqb5oC4sfOklv6Kbbf-T3RvUobMSLrzyXNbfNVT9vMxJGuY1RsSqbc6MjpIABre1Q$> Abstract: LRRK2 serine/threonine kinase is associated with inherited Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their switch 2 motif to control their interactions with effectors. Recent work has shown that the metal-dependent protein phosphatase PPM1H counteracts LRRK2 by dephosphorylating Rabs. PPM1H is highly selective for LRRK2 phosphorylated Rabs, and closely related PPM1J exhibits no activity toward substrates such as Rab8a. We have identified the structural determinant of PPM1H specificity for Rabs. The crystal structure of PPM1H reveals a conserved catalytic domain punctuated by a 110-residue flap domain adjacent to the active site. Biochemical and cellular assays suggest that the flap domain of PPM1H encodes the docking motif for phosphorylated Rabs. Bio: Amir Khan graduated with a PhD from the University of Alberta, Canada. He performed post-doctoral work with Don Wiley at Harvard University, and also with Anne Houdusse at Institut Curie, Paris. It was in Paris that he became interested in Rab GTPases and their interactions with effector proteins. In recent years, he has become interested in how Rab control of membrane trafficking intersects with neurodegeneration in the context of Parkinson’s disease. He recently joined Trinity College at Dublin. Associate Professor at Trinity College Dublin ================== Vivian Stojanoff, PhD Education, Training, Outreach User Program p 1(631) 344 8375 e lifesciences@<mailto:nsls.lifescien...@gmail.com>bnl.gov w https://www.bnl.gov/ps/lifesciences/<https://www.bnl.gov/ps/lsbr/> Address: Center for Biomolecular Structure National Synchrotron Light Source II Building 745 Brookhaven National Laboratory Upton NY 11973 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
