[Icon Description automatically generated with low confidence]Targeting the replication machinery of Nipah virus We are seeking three ambitious and highly motivated research scientists to join a project funded by PAD – Pandemic Antiviral Discovery – which is a global philanthropic initiative launched by the Bill & Melinda Gates Foundation and Open Philanthropy in the US, and the Novo Nordisk Foundation (NNF) in Denmark. The scientists will join the laboratories of Professor Jonathan Grimes at the Division of Structural Biology, Professor Miles Carroll at the Pandemic Sciences Institute and Professor Ervin Fodor at the Sir William Dunn School of Pathology within the University of Oxford and will join a dynamic and successful team of virologists, biochemists and structural biologists studying the fundamental molecular mechanisms of virus replication. The project that seeks to elucidate the molecular determinants of henipavirus replication, pathogenesis and transmission for the purpose of developing therapeutic discovery programs targeting virus and/or host-specific targets important for virus replication. The project sits under the umbrella of the Pandemic Science Institute ( https://www.psi.ox.ac.uk/what-we-do) which is an exciting, high-profile new venture of the University of Oxford . The Institute will build on Oxford’s world leading response to the Covid pandemic, bringing together expertise from across the University and across the world to make the world safer through science. The three positions would suit enthusiastic and highly organised postdoctoral scientists with an interest in viral replication and possessing the ability to contribute conceptually to the overall research programme. The research program will require a team with skills ranging from eukaryotic tissue culture expression, virus handling and purification, protein expression and purification through to protein crystallography and electron and fluorescence microscopy. The three postdoctoral fellows will each be assigned primarily to one of the three work packages: one will take the lead in driving the structural analyses forward, the second on the development of the drug screening and the third on the assay development and biochemistry of the replicase complex. Applicants must hold, or be close to completion of, a PhD in biochemistry, molecular biology, biophysics or related sciences. Previous research published in peer-reviewed scientific journals or as pre-print, good communication skills and experience in advanced molecular biology techniques and experimentation are essential. If you are interested in the positions, please apply online through https://www.jobs.ox.ac.uk/; Vacancy ID: 162453, 162062 and 162059. You will be required to upload a CV and supporting statement as part of your online application. The position is funded by the Bill & Melinda Gates Foundation and Open Philanthropy in the US, and the Novo Nordisk Foundation (NNF) and is for a three year fixed term (31 Dec 2025) with a possibility of extension. The closing date for applications is 12.00 midday on 13 January. Interviews will be held as soon as possible thereafter.
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