Senior/Research Scientist (Protein Biochemist), Protein Structure & Biophysics Group
Make your mark for patients. We're here because we want to build the future and transform patients' lives for the better. At UCB, our people are our experiences and achievements, our passion and drive. That's why we're looking for talented individuals with diverse backgrounds and experiences - not just the best and brightest, but those who care about making a meaningful difference in the lives of patients. We promote an environment of diversity, openness, and respect where people can make valuable contributions. An exciting journey lies ahead. Will you join us in pushing the boundaries of what's possible? UCB has an excellent track record in utilising structural information in the development of both small molecule and antibody therapeutics. To support this capability, we have an exciting opportunity for a protein biochemist to join the Protein Structure & Biophysics (PS&B) department and contribute to UCB's goal of bringing real benefits to patients. We are looking for an innovative, enthusiastic protein biochemist to join the Protein Production team, generating high quality protein reagents to support all aspect of UCB's drug discovery process. The role offers the opportunity to work alongside a dynamic and diverse group of scientists that make up the PS&B department and to interact with the wider research organisation on our drug discovery programs. Responsibilities * Work independently in the production of protein reagents with the opportunity to take a lead role in strengthening our capability in the expression and purification of multi-pass membrane proteins. * Collaborate with other members of the PS&B department and across multiple disciplines (project teams, medicinal chemistry, antibody discovery and the CADD group) to collectively bring value to our therapeutic projects. * Interpret and communicate experimental data at cross-functional meetings, highlighting technical challenges and providing potential solutions. * Keep abreast of and implement technology developments within the area of protein expression and purification with a key focus on multi-pass membrane proteins. Profile Candidates will have a PhD (or graduate with 4-5 years' experience) with significant hands-on experience in recombinant protein production. Preference will be given to candidates experienced in the production of both soluble and membrane proteins. We are looking for candidates who can demonstrate the following skill sets: * Ability to interrogate protein structures to optimize expression construct design. * Familiar with a range of expression systems including: E. coli, insect cells and mammalian cells. * Fully independent in protein purification techniques and extensive working knowledge of AKTA purification platforms and associated software. * Knowledge of and ideally hands-on experience in producing membrane proteins in nano-discs, liposomes and SMALPS. * An awareness of, and preferably hands-on experience in the techniques required in generating multi-pass membrane proteins for structural studies. * Not essential, but good to have experience of performing structure determination and/or mass spec analysis of membrane proteins. In addition, all applicants must possess excellent written and verbal communication skills. Only candidates able to work in the EU will be considered for this role. To apply, please send your CV and motivation letter to protein.purificat...@ucb.com<mailto:protein.purificat...@ucb.com> UCB will not accept unsolicited or speculative applications from recruitment agencies or suppliers without prior agreement in place. ________________________________ Legal Notice: This electronic mail and its attachments are intended solely for the person(s) to whom they are addressed and contain information which is confidential or otherwise protected from disclosure, except for the purpose for which they are intended. Dissemination, distribution, or reproduction by anyone other than the intended recipients is prohibited and may be illegal. If you are not an intended recipient, please immediately inform the sender and return the electronic mail and its attachments and destroy any copies which may be in your possession. UCB screens electronic mails for viruses but does not warrant that this electronic mail is free of any viruses. UCB accepts no liability for any damage caused by any virus transmitted by this electronic mail. (Ref: #*UG1107) [Ref-UG1107] ________________________________ ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
