Dear All,

Please suggest me a program to compute the pairwise CA-distance plots of
residues in other subunits after superposition of one particular subunit.
My enzyme is a homotetrameric one and upon binding of a substrate there are
changes in relative orientations among four subunits (i.e., allosteric
effects). Therefore, I would like to superpose one particular subunit
between an unliganded and a substrate-bound structure, and compute the
pairwise CA-distance plots of equivalent residues in other three subunits.
By using these approaches, I could find out a relative movement of subunits
in a tetramer..

 

Thanks in advance

Sangkee

 

 

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Sangkee Rhee, Ph.D.

College of Agrculture & Life Sciences

Seoul National University

SEOUL, KOREA

 

e-mail:  srhee...@snu.ac.kr <mailto:srhee...@snu.ac.kr> 

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