Dear All

Please find the details below for a postdoctoral position in the Weiss/Takagi 
labs:

All the best

Yuro

Yuichiro H. Takagi, Ph.D.
Associate Professor
Scientific director of cryo-EM
Department of Biochemistry and Molecular Biology
Indiana University School of Medicine
https://twitter.com/LabTakagi

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Postdoctoral opportunity for structure studies of the insulin analogues - 
insulin receptor complex by cryo-EM at Indiana University School of Medicine, 
Indianapolis, IN USA

We invite applications for a post-doctoral position, funded by the NIH and 
Helmsley Charitable Trust, focusing on cryo-EM studies of how insulin analogs 
bind to the insulin receptor at the laboratory of Dr. Michael A. Weiss at 
Department of Biochemistry & Molecular Biology, Indiana University School of 
Medicine (IUSM). This project is in collaboration with the lab of Dr. Yuichiro 
Takagi at IUSM. Analogs include ultra-stable and glucose-responsive insulin 
variants of clinical interest – please see our latest publication in this 
subject: https://www.pnas.org/doi/10.1073/pnas.2103518118

The Indiana University School of Medicine (IUSM) has an EM Core with 200 kV 
Glacios cryo-EM with Falcon 4 camera and shared access to a 300 kV Titan Krios 
G4 with K3 camera, located at Purdue University as part of a regional 
consortium. The post-doctoral fellow will be part of a multidisciplinary team 
including synthetic peptide chemists and cell biologists engaged in insulin 
research with translational application to the improved treatment of diabetes 
mellitus. A PhD in structural biology or computation protein chemistry is 
required. Prior experience with cryo-EM is preferred but not required. We will 
provide an extensive in-house cryo-EM training. IUSM provides a diverse 
international community and welcomes applications from scientists of diverse 
backgrounds, cultures, nationalities and genders. Non-US Citizens will require 
an appropriate Visa for employment in the United State.

If interested, please submit Curriculum Vitae (CV), letter of introduction and 
names of three referees (including prior or current laboratory mentors) via the 
link below:

https://indiana.peopleadmin.com/postings/12738

If you have any question, please contact Drs. Yuichiro Takagi and Michael A. 
Weiss, Department of Biochemistry & Molecular Biology, Indiana University 
School of Medicine, Indianapolis, IN 46202 (email addresses 
ytak...@iu.edu<mailto:ytak...@iu.edu> and weis...@iu.edu<mailto:weis...@iu.edu>)













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