Dear all, I would be grateful if you would please circulate this PhD
opportunity to potential candidates in your network. Many thanks.


*PhD project: Drug discovery at the interface of DEL screening, cryo EM and
AI machine learning*



A 4-year fully-funded PhD position is available in Wyatt Yue’s lab
<https://www.staff.ncl.ac.uk/yuelab/> at Newcastle University, under the
MoSMed CDT <https://research.ncl.ac.uk/mosmed/> programme at Newcastle and
Durham (UK).



The project builds on the lab's track record in structural studies of human
metabolic enzymes, to discover chemical starting points for inhibitor
design, through working closely with medicinal (Mike Waring) and
computational (Daniel Cole) chemists at the university, as well as an AI
drug discovery company (Standigm Inc).



The student will receive training in protein biophysics and cryo-EM (Yue),
and have hands-on experience in DNA-encoded library screening (Waring),
protein-ligand simulations (Cole), and machine learning compound design
(Standigm).



Details of the project as well as instructions on how to apply can be found
here: NBDTP (ncl.ac.uk)
<https://research.ncl.ac.uk/media/sites/researchwebsites/mosmed/22_07%20A%20novel%20drug%20discovery%20workflow%20combining%20DNA-encoded%20library,%20AI%20machine%20learning,%20and%20cryo-electron%20microscopy.pdf>



The studentship is open to UK/EU/international applicants, with
deadline on *23:59
GMT Wednesday 2nd March*.



Enquiries on the project can be emailed to wyatt....@newcastle.ac.uk

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