Dear all The Kulathu Lab at the MRC PPU, University of Dundee is looking to hire a postdoc with strong expertise in biochemistry and structural biology to address exciting questions about how the pseudokinases IRAK2 and IRAK3 regulate innate immune signalling.
The innate immune response is the first line of defence against bacteria, viruses and parasites. When innate immune receptors are triggered, the IRAK kinases are activated to trigger a signalling cascade that culminates in the expression and secretion of cytokines that shape the immune response to invading pathogens. There are 4 IRAK kinases expressed in humans, two of which (IRAK2 and IRAK3) lack key catalytic residues and are therefore dead kinases or pseudo-kinases. The aim of this project will be to understand the molecular mechanisms by which these dead kinases regulate immune signalling. This project will build on recently published work1 and utilize protein biochemistry, cryo-electron microscopy, X-ray crystallography to define how IRAK kinases are activated and regulated. This project has the potential to reveal fundamental principles underlying the activation and regulation of innate immune signalling, and reveal how they could be modulated to treat inflammatory diseases such as arthritis, artherosclerosis, systemic lupus erythematosus and psoriasis. This work will be a collaborative project with Sir Philip Cohen. 1Lange et al. Structure 2020. DOI: https://doi.org/10.1016/j.str.2020.11.004 Who we're looking for: We are looking for a talented, motivated individual with a PhD (or nearing completion of your PhD) in Biochemistry, Structural biology or a related field. Candidates will be expected to have expertise in the following areas: · Recombinant protein expression and purification · In vitro reconstitution and characterization of multiprotein complexes · Biochemistry, enzyme kinetics · Structural biology You will have a track record of research productivity and have demonstrated an ability to work independently, enthusiasm for research and excellent communication skills. It is expected that the candidate will develop and apply a broad range of techniques to pursue the research objectives. To apply on-line, please visit www.dundee.ac.uk/jobs<https://www.dundee.ac.uk/jobs/> (please quote reference number SLSC0989) and submit a single PDF file that contains: · A curriculum vitae. Please include list of publications and submissions to Biorxiv with a brief description of your contribution to the work. · A cover letter that outlines your current research, research interests, career goals and a brief summary highlighting your expertise in biochemistry, structure-function analyses and/or cell biology. Informal enquiries may be directed to Yogesh Kulathu ykula...@dundee.ac.uk<https://www.jobs.dundee.ac.uk/fe/ykula...@dundee.ac.uk>. As an internationally diverse institution, we welcome job applicants from all countries and nationalities. The School of Life Sciences is proud to employ staff from over 40 different nations and provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities. See here for more details on this position and working at the University of Dundee: https://www.ppu.mrc.ac.uk/careers/recruitment/postdoctoral-research-assistant-slsc0989 Thank you Yogesh ------------------------------------------ Yogesh Kulathu (he/him) MRC Investigator MRC Protein Phosphorylation & Ubiquitylation Unit The Sir James Black Centre School of Life Sciences, University of Dundee Dundee DD1 5EH, Scotland, UK. ykula...@dundee.ac.uk<mailto:ykula...@dundee.ac.uk> Kulathu Lab Website<https://www.ppu.mrc.ac.uk/groups/yogesh-kulathu/> Twitter: @YKulathu<https://twitter.com/YKulathu> The University of Dundee is a registered Scottish Charity, No: SC015096 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
