The Tan lab in sunny Singapore is looking for a post-doctoral candidate who will work with Assistant Professor Tan Yong Zi on biochemistry and structural biology under a project entitled Understanding the Structure and Function of Mammalian Membrane Proteins Involved in Human Diseases.
While membrane proteins only make up around 20% of the proteome, they constitute around 60% of drug targets. However, high resolution structural information is severely lacking for them, with only about 2% of the structures deposited in the public protein database (PDB) being annotated as membrane proteins. The Tan lab (www.tyzlab.com<http://www.tyzlab.com>) strives to fill in this gap by targeting membrane proteins involved in human diseases such as cancer and diabetes. Our forte is using state-of-the-art single-particle cryogenic electron microscopy (cryo-EM) to obtain high-resolution atomic structures of these membrane proteins. We also actively work on methods development in cryo-EM that will help us answer our biological questions. The Tan lab is generously funded by the NUS Presidential Young Professorship under the Department of Biological Sciences, NUS. We are a core member of the Centre for BioImaging Sciences' (CBIS), and have access to high-end cryo-EM microscopes, including a Titan Krios with K3 direct detector and energy filter. Main Responsibilities * Lead structural projects from protein expression, protein purification, activity assay, cryo-EM imaging, data processing to model building Application Requirements * Candidates must uphold values of scientific integrity, honesty, teamwork and pride in their work * PhD in Biology/Biochemistry/Biophysics/Biotechnology or related field * Experience with bacterial, insect and mammalian cell culture work is not essential but favoured * Experience in protein purification experience is required * Programming (such as Python) skills not essential but favoured * Structural biology experience not essential but favoured Interested candidates please contact me at yz...@nus.edu.sg<mailto:yz...@nus.edu.sg>. Please provide a CV and names and contact of three referees. Warmest Regards, Yong Zi Tan Assistant Professor Department of Biological Sciences National University of Singapore www.tyzlab.com<http://www.tyzlab.com> ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
