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Center for Biomolecular Structure Lecture Series Incorporating HT-SAXS into Structure-Driven Drug Discovery Pipelines Chris Brosey M.D. Anderson Cancer Center, The University of Texas WEDNESDAY, September 22, 13:30 (EST - NY time zone) Register in advance for this meeting: https://bnl.zoomgov.com/meeting/register/vJIsfu6przwpH8NymLh_TKxtg09_NaMkFFs Abstract: High-throughput (HT) methods for discovering single-target protein and nucleic acid ligands are well established and routinely utilized for drug discovery. Many critical biological outcomes, however, are mediated by multi-component assemblies and dynamic macromolecular architectures. HT approaches to assess and fine-tune ligand impact on such functional, dynamic systems remain underdeveloped. Small-angle X-ray scattering (SAXS) provides an opportunity to monitor changes to biomolecular architectures and assemblies under native solution environments, enabling chemical screening and selection for specific architectural states. I will discuss how we have incorporated time-resolved HT-SAXS into a classic fragment screening pipeline and used this approach to identify chemical allosteric effectors targeting functional architectures of mitochondrial Apoptosis-Inducing Factor (AIF) ----------------------------------------------- Vivian Stojanoff, PhD Education, Training, Outreach User Program p 1(631) 344 8375 e nsls.lifescien...@gmail.com<mailto:nsls.lifescien...@gmail.com> w https://www.bnl.gov/ps/lifesciences/<https://www.bnl.gov/ps/lsbr/> Address: Center for Biomolecular Structure National Synchrotron Light Source II Building 745 Brookhaven National Laboratory Upton NY 11973 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
