Scientist in Protein Crystallography (PhD) ZoBio (www.zobio.com) was founded in 2004 and is located in Leiden, Netherlands. We offer innovative research services in the field of small-molecule drug discovery to the pharmaceutical and biotech industries. Our international team of 33 people covers four fields of expertise: Protein Engineering and Production, Assay Development and Screening, Structural Biology and Medicinal Chemistry.
We are currently looking to strengthen our team with an *X-ray crystallographer* with a track record in protein crystallography and a strong background in X-ray crystallographic data analysis. Experience in building and refinement of protein-small-molecule complexes would be extremely helpful. You will support our clients’ drug discovery programs by solving ligand-protein structures. You will work with minimal supervision but in a highly collaborative environment within the Structural Biology team and will effectively cooperate on a per-project basis with other research groups at ZoBio. Your role will require working simultaneously on multiple projects in a rapidly evolving environment. Team spirit and excellent organization and communication skills are essential. *TASKS & RESPONSIBILITIES* - High-throughput crystallographic screening utilizing automation and robotics - High-throughput and -quality structure elucidation and interpretation of biological macromolecules in complexes with small molecules of interest - Utilization of X-ray crystallography pipelines with the aid of computational structural biology tools to aid the efficient structure elucidation of protein-ligand complexes - Prepare presentations on the structural data for project teams and clients - Maintain up-to-date understanding of the current state of the field in X-ray crystallography in relation to modern drug discovery challenges *REQUIREMENTS* - PhD in relevant field with experience in an industrial or collaborative setting - Hands-on experience with ligand modelling into electron density maps and macromolecular model building and refinement in the context of Structure-Based Drug Discovery campaigns - Hands-on experience in solving challenging X-ray crystallography cases (e.g.*ab initio* structure solution) - Experience with computational structural biology tools such as ligand docking, virtual screening, and molecular dynamics simulation would be considered an advantage - Experience in scripting and programming would be considered an advantage - Ability to work in a team in a result-driven, goal-oriented environment It is fully expected that you will become a permanent and integral member of the ZoBio team after an initial period of 12 months. Applicants at either the Senior Scientist or Scientist level will be considered. A tailored remuneration package will be proposed in line with individual qualifications and experience. The position is immediately available; the evaluation and assessment of candidates will run until the position is filled. Please send your CV, motivation letter and names of potential referees at < h...@zobio.com*>* with the subject: “Scientist in Protein Crystallography”. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
