One short cut would be to focus on Pfam families that do not yet have a 3D representative. They can be browsed eg
https://pfam.xfam.org/family/browse?browse=a or you can also install Pfam locally as MySQL for programmatic access. Choosing Families rather than Domains would make it easier to get proteins matching only a single Pfam entry If you wanted to be more stringent you could exclude any families that were in Clans that had a structural representative. Dan Prof Daniel Rigden (He/Him) Department of Biochemistry and Systems Biology Institute of Systems, Molecular and Integrative Biology Room 101, Biosciences Building University of Liverpool Crown St., Liverpool, L69 7ZB (+44) 151 795 4467 www.liverpool.ac.uk/integrative-biology/staff/daniel-rigden/ ________________________________ From: CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK> on behalf of Scott Horowitz <scott.horow...@du.edu> Sent: 07 June 2021 21:00:42 To: CCP4BB@JISCMAIL.AC.UK Subject: [ccp4bb] looking for proteins with no homologues in pdb For testing purposes, we want to solve structures of proteins that are not in the PDB and have no significant sequence homologues in the PDB (i.e. a blast of the pdb will get no significant hits). Does anyone happen know a good way to find such proteins efficiently? Having an interesting function isn't needed. Thanks, Scott Scott Horowitz, Ph.D. Assistant Professor Department of Chemistry & Biochemistry Knoebel Institute for Healthy Aging University of Denver ECS Building 2155 E. Wesley Ave Denver, CO 80208 Phone: 303-871-4326 Fax: 303-871-7915 Zoom Room: https://udenver.zoom.us/my/scotthorowitz Email: scott.horow...@du.edu Office: Room 561 Lab: Room 505 ________________________________ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
