Dear Madams, dear Sirs,
I hope this message finds you in good health.
I would very much appreciate it if you could post the attached advert
for a postdoctoral position.
(It is in ASCII, i.e., plain text, format but I can also prepare a pdf
document if needed).
Thank you in advance.
Sincerely,
Amedeo Caflisch
*cafli...@bioc.uzh.ch
*Director
Department of Biochemistry
University of Zurich
===========================================================================
*University of Zurich
Department of Biochemistry*
Postdoctoral researcher in cryo-EM
The research groups of Prof. Amedeo Caflisch (Department of
Biochemistry) and Prof. Cristina Nevado (Department of Chemistry) at the
University of Zurich are looking for a post-doctoral associate with
strong experience in cryo-electron microscopy and single-particle analysis.
The researcher is expected to contribute expertise in single-particle
cryo-EM to support ongoing collaborative projects aiming at the
optimization and characterization of in-house designed proteolysis
targeting chimeric (PROTAC) molecules that show nanomolar affinity on
cancer-relevant targets. On a second stage, the postdoctoral researcher
will have the possibility to manage her/his own independent research
project within the main research focus areas of the host laboratory. The
researcher will have access to the Center for Microscopy and Image
Analysis in the same building on campus
https://www.zmb.uzh.ch/en/Instruments-and-tools/ElectronMicroscopes.html
Your responsibilities
The activities of this position involve mainly:
* Protein expression (mainly in /E. coli/) and purification
* Cryo-EM sample handling and preparation protocols including negative
staining and sample vitrification
* Process single particle cryo-EM data including handling raw data,
interpretation, 3D reconstruction and map refinement, and model building
* Structure-based optimization of small-molecule ligands and PROTACs
Your profile
Experience on data-processing and structure solution of *small size
protein complexes (<150 kDa)* is desired. The candidate should be about
to receive their PhD degree or have less than three years of previous
post-doctoral experience. Applications from senior researchers will not
be considered.
What we offer
Our well-funded drug discovery research program combines inspiring
international research environment with access to state-of-the-art
scientific infrastructure. Our alumni value their comprehensive
training: about 25% of them are offered a tenure track assistant
professorship position, with the vast majority of the rest finding
employment in large pharma or biotech industry.
Place of work
Irchel campus, CH-8057 Zurich, Switzerland
Start of employment
Starting date: by arrangement (immediate entry possible).
Length: 3 years with an initial 1-year contract.
Applications are to be submitted as a single PDF file to
*cafli...@bioc.uzh.ch*
and must contain a cover letter, a concise summary of past
accomplishments in cryo-EM, a CV (of maximum two pages), and at least
one letter of support or the names and contact details of two (former)
advisors.
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