Dear John, Your article touches all the important points about this breakthrough and its caveats. I would just like to add that the ligand problem is of a different order: it is fundamentally not about whether, where and how a ligand is predicted to bind, but rather about whether it indeed binds where and in the way it is predicted to. So I daresay that it is an irreducibly experimental problem. Best, Emmanuel
Dr Emmanuel Saridakis National Centre for Scientific Research DEMOKRITOS Athens, Greece ----- Original Message ----- From: John R Helliwell <jrhelliw...@gmail.com> To: CCP4BB@JISCMAIL.AC.UK Sent: Tue, 08 Dec 2020 15:15:14 +0200 (EET) Subject: Re: [ccp4bb] AlphaFold: more thinking and less pipetting (?) Dear Isabel, My article in the IUCr Newsletter on DeepMind and CASP14 is released today and can be found here:- https://www.iucr.org/news/newsletter/volume-28/number-4/deepmind-and-casp14 Best wishes, John Emeritus Professor John R Helliwell DSc > On 3 Dec 2020, at 11:17, Isabel Garcia-Saez <isabel.gar...@ibs.fr> wrote: > > > Dear all, > > Just commenting that after the stunning performance of AlphaFold that uses AI > from Google maybe some of us we could dedicate ourselves to the noble art of > gardening, baking, doing Chinese Calligraphy, enjoying the clouds pass or > everything together (just in case I have already prepared my subscription to > Netflix). > > https://www.nature.com/articles/d41586-020-03348-4 > > Well, I suppose that we still have the structures of complexes (at the > moment). I am wondering how the labs will have access to this technology in > the future (would it be for free coming from the company DeepMind - Google?). > It seems that they have already published some code. Well, exciting times. > > Cheers, > > Isabel > > > Isabel Garcia-Saez PhD > Institut de Biologie Structurale > Viral Infection and Cancer Group (VIC)-Cell Division Team > 71, Avenue des Martyrs > CS 10090 > 38044 Grenoble Cedex 9 > France > Tel.: 00 33 (0) 457 42 86 15 > e-mail: isabel.gar...@ibs.fr > FAX: 00 33 (0) 476 50 18 90 > http://www.ibs.fr/ > > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/ -- Dr. Emmanuel Saridakis Principal Researcher Institute of Nanoscience and Nanotechnology National Centre for Scientific Research "DEMOKRITOS" 15310 Athens GREECE tel: +30-2106503793 email: e.sarida...@inn.demokritos.gr ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
