It is a major leap forward for structure prediction for sure. A hearty
congratulations to all those teams over all those years.
The part I don't understand is the accuracy. If we understand what
holds molecules together so well, then why is it that when I refine an
X-ray structure and turn the X-ray weight term down to zero ... the
molecule blows up in my face?
-James Holton
MAD Scientist
On 12/3/2020 3:17 AM, Isabel Garcia-Saez wrote:
Dear all,
Just commenting that after the stunning performance of AlphaFold that
uses AI from Google maybe some of us we could dedicate ourselves to
the noble art of gardening, baking, doing Chinese Calligraphy,
enjoying the clouds pass or everything together (just in case I have
already prepared my subscription to Netflix).
https://www.nature.com/articles/d41586-020-03348-4
<https://www.nature.com/articles/d41586-020-03348-4>
Well, I suppose that we still have the structures of complexes (at the
moment). I am wondering how the labs will have access to this
technology in the future (would it be for free coming from the company
DeepMind - Google?). It seems that they have already published some
code. Well, exciting times.
Cheers,
Isabel
Isabel Garcia-SaezPhD
Institut de Biologie Structurale
Viral Infection and Cancer Group (VIC)-Cell Division Team
71, Avenue des Martyrs
CS 10090
38044 Grenoble Cedex 9
France
Tel.: 00 33 (0) 457 42 86 15
e-mail: isabel.gar...@ibs.fr <mailto:isabel.gar...@ibs.fr>
FAX: 00 33 (0) 476 50 18 90
http://www.ibs.fr/
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