To any driven and motivated early career scientists out there,

A Postdoctoral Associate position is available based at the Hauptman-Woodward 
Medical Research Institute (HWI) in Buffalo New York and affiliated with the 
University at Buffalo. We are a welcoming environment looking for a highly 
motivated structural biologist with an interest in metalloproteins and methods 
development to join a project with the 
Snell<https://hwi.buffalo.edu/scientist-directory/snell/> and 
Bowman<https://hwi.buffalo.edu/scientist-directory/sbowman/> laboratories. The 
project involves the structural study of biological systems that are impacted 
by free radical activity and metalloproteins, where the modeled metal and/or 
coordination state are of interest for further investigation. The work will 
involve a collaboration with well-known scientists in Stanford and Oxford and 
will use X-ray crystallography, UV-spectroscopy, and micro-PIXE techniques. The 
eventual aim involves structural studies using X-ray free-electron sources for 
radiation chemistry-free data. It is possible that neutron studies would also 
take place. The position involves working directly with the Crystallization 
Center<https://hwi.buffalo.edu/high-throughput-crystallization-center/> at the 
Institute and will have access to a Glacios cryo-EM with Falcon 4 detector. The 
Institute runs the IMCA beamline at the Advanced Photon Source. It is 
anticipated that multiple structural techniques will be employed, and while the 
candidate should have structural biology expertise, they are not expected to be 
proficient in all structural biology techniques. Molecular biology expertise is 
required to produce target proteins and complexes. Many techniques will be 
employed and significant learning opportunities are available.

This position is based at HWI but offered through the University at Buffalo. 
Informal enquiries only can be made to Doctor's Snell and Bowman (email details 
on their webpages). Application instructions and details are available at the 
University of Buffalo job posting 
site<https://www.ubjobs.buffalo.edu/postings/26915>.

Publications related to the project are available at the Snell lab webpage at 
https://hwi.buffalo.edu/scientist-directory/snell/ with pertinent publications 
at https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239702 
and https://pubs.acs.org/doi/pdf/10.1021/jacs.9b09186.

Dr. Bowman's webpage is at 
https://hwi.buffalo.edu/scientist-directory/sbowman/. Dr Bowman is director of 
the High-throughput Crystallization Screening laboratory at 
https://getacrystal.com, available for rapid and productive crystallization 
screening of biological macromolecules.

Sincerely,

Edward Snell

Edward Snell Ph.D.

President and CEO | Hauptman-Woodward Medical Research Institute
Director | NSF BioXFEL Science and Technology Center
BioInnovations Chaired Professorship | University at Buffalo, SUNY

p: +1 716 898 8631 | f: +1 716 898 8660
e: esn...@hwi.buffalo.edu<mailto:esn...@hwi.buffalo.edu>
skype: eddie.snell

Hauptman-Woodward Medical Research Institute
700 Ellicott Street | Buffalo, NY 14203-1102
hwi.buffalo.edu<https://hwi.buffalo.edu/>


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