Dear all,
This is a friendly reminder that deadline approaching open post at ZoBio

On Mon, 13 Jul 2020, 17:16 Denys Pogoryelov, <xtalaba...@gmail.com> wrote:

Scientist X-ray Crystallography at ZoBio in Leiden (NL)

ZoBio (www.zobio.com) was founded in 2004 and is located in Leiden, 
Netherlands. We offer innovative research services in the field of 
small-molecule drug discovery to the pharmaceutical and biotech industries. Our 
international team of 26 people covers four fields of expertise: Protein 
Engineering and Production, Assay Development and Screening, Structural Biology 
and Medicinal Chemistry.

We are currently looking to strengthen our team with the X-ray crystallographer 
with a track record in the protein crystallography and a strong background in 
the X-ray crystallographic data analysis. In particular, experience in building 
and refinement of protein – small-molecule complexes would be extremely helpful.

The successful applicant will support our clients’ drug discovery programs by 
solving ligand-protein structures. You will work with minimal supervision but 
in a highly collaborative environment within the Structural Biology team and 
will effectively cooperate on a per-project basis with other research groups at 
ZoBio. This role requires working on multiple projects simultaneously and in a 
rapidly evolving environment. Team spirit and excellent organization and 
communication skills are essential.

RESPONSIBILITIES  
•        High-throughput and -quality structure elucidation and interpretation 
of biological macromolecules in complexes with small molecules of interest. 

•        Integration and streamlining X-ray crystallography pipelines with the 
aid of computational structural biology tools to aid the efficient structure 
elucidation of protein-ligand complexes.

•        Report results to the Head of Crystallography and prepare 
presentations on the structural data for the project teams and clients.

•        Maintain up-to-date understanding of the state-of-the-field in X-ray 
crystallography in relation to modern drug discovery challenges. 

REQUIREMENTS
•        PhD in relevant field with experience in an industrial or 
collaborative setting. 

•        Hands-on experience with ligand modelling into electron density maps 
and macromolecular model building and refinement in the context of 
Structure-Based Drug Discovery campaigns.

•        Hands-on experience in solving challenging X-ray crystallography cases 
(e.g. ab initio structure solution).

•        Experience in scripting in Bash/Python and integration of the X-ray 
crystallography routines. 

•        Experience with computational structural biology tools like ligand 
docking, virtual screening, molecular dynamics simulation would be considered 
as an advantage.

•        Able to work in a team in a result-driven, goal-oriented environment.

It is fully expected that you will become a permanent and integral member of 
the ZoBio team, after an initial period of 12 months. However, applicants 
opting for remote and/or flexible working arrangements will also be considered. 
Applicants at the Senior Scientist or Scientist level will be considered. 

A tailored remuneration package will be proposed in line with individual 
qualifications and experience. The position is immediately available; the 
evaluation and assessment of candidates will run until the position is filled 
but not later than the end of August 2020.  

Please send your CV, motivation letter and names of potential referees at 
<i...@zobio.com> with the subject: “Scientist position in X-ray 
Crystallography”. 

------------------------------------------------------------------------------------------------------------------------------------------

Scientist X-ray Crystallography at ZoBio in Leiden (NL) 

ZoBio (www.zobio.com) was founded in 2004 and is located in Leiden, 
Netherlands. We offer innovative research services in the field of 
small-molecule drug discovery to the pharmaceutical and biotech industries. Our 
international team of 26 people covers four fields of expertise: Protein 
Engineering and Production, Assay Development and Screening, Structural Biology 
and Medicinal Chemistry. 

We are currently looking to strengthen our team with an X-ray crystallographer 
with a track record in protein crystallography and a strong background in the 
X-ray crystallographic data analysis. In particular, experience in building and 
refinement of protein – small-molecule complexes would be extremely helpful. 

The successful applicant will support our clients’ drug discovery programs by 
solving ligand-protein structures. You will work with minimal supervision but 
in a highly collaborative environment within the Structural Biology team and 
will effectively cooperate on a per-project basis with other research groups at 
ZoBio. This role requires working on multiple projects simultaneously and in a 
rapidly evolving environment. Team spirit and excellent organization and 
communication skills are essential. 

RESPONSIBILITIES  

• High-throughput and -quality structure elucidation and interpretation of 
biological macromolecules in complexes with small molecules of interest.  

• Integration and streamlining X-ray crystallography pipelines with the aid of 
computational structural biology tools to aid the efficient structure 
elucidation of protein-ligand complexes. 

• Report results to the Head of Crystallography and prepare presentations on 
the structural data for the project teams and clients. 

• Maintain up-to-date understanding of the state-of-the-field in X-ray 
crystallography in relation to modern drug discovery challenges.  

REQUIREMENTS 

• PhD in relevant field with experience in an industrial or collaborative 
setting.  • Hands-on experience with ligand modelling into electron density 
maps and macromolecular model building and refinement in the context of 
Structure-Based Drug Discovery campaigns. • Hands-on experience in solving 
challenging X-ray crystallography cases (e.g. ab initio structure solution). • 
Experience in scripting in Bash/Python and integration of the X-ray 
crystallography routines.  • Experience with computational structural biology 
tools like ligand docking, virtual screening, molecular dynamics simulation 
would be considered as an advantage. • Able to work in a team in a 
result-driven, goal-oriented environment. 

It is fully expected that you will become a permanent and integral member of 
the ZoBio team, after an initial period of 12 months. However, applicants 
opting for remote and/or flexible working arrangements will also be considered. 
Applicants at either the Senior Scientist or Scientist level will be 
considered.  

A tailored remuneration package will be proposed in line with individual 
qualifications and experience. The position is immediately available; the 
evaluation and assessment of candidates will run until the position is filled 
but not later than the end of August 2020.   

Please send your CV, motivation letter and names of potential referees at 
<i...@zobio.com> with the subject: “Scientist position in X-ray 
Crystallography”.

------------------------------------------------------------------------------------------------------------------------------------------

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