Hi Tim, thank you for your reply. The 1998 Schenk paper is "new" to me, I had seen this one: https://science.sciencemag.org/content/sci/364/6441/667.full.pdf The background of my question was about the status in practice: Is it possible to routinely determine the absolute configuration of small molecules by electron diffraction, or is it something that in theory can be done, but only difficult in practice?
Best, Herman -----Ursprüngliche Nachricht----- Von: Tim Gruene <tim.gru...@univie.ac.at> Gesendet: Montag, 20. Juli 2020 11:03 An: CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK>; Schreuder, Herman /DE <herman.schreu...@sanofi.com> Betreff: [EXTERNAL] chirality with electron diffraction EXTERNAL : Real sender is tim.gru...@univie.ac.at Dear Herman, The absolute configuration can be determined, although very differently from X-ray ccrystallography. So far, two different experimental approaches have been published: Ma, Oleynikov, Terasaki (2017), https://doi.org/10.1038/nmat4890 and Brazda et al (2019), 10.1126/science.aaw2560 The former is based on imaging, the latter is based on dynamical refinement: Jansen, Tang, Zandbergen, Schenk (1998), https://doi.org/10.1107/S0108767397010489 There is a very interesting paper by Burmester and Schroeder Scanning Microscopy Vol. 11, 1997 (Pages 323-334). According to this paper, the anomalous signal in ED is actually stronger than in X-ray crystallography. As far as I know, this has not been pursued further. Best wishes, Tim P.S.: This is a response to your email to Jessica Bruhns in the thread 'quote source inquiry'. This thread has reached an overflow, so I took the liberty to adjust the subject. -- -- Tim Gruene Head of the Centre for X-ray Structure Analysis Faculty of Chemistry University of Vienna Phone: +43-1-4277-70202 GPG Key ID = A46BEE1A ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
