Hi Nick - it is we that thank you all; and apologies for the tight
deadlines, all I can say is we'd be a bit more thoughtful but CoV-2 is
not being particularly obliging either...
There will be at least one more round, deadline approximately one week
later; and we may have additional fragments because Diamond came back
up this week, just for COVID work.
Speaking of which: reminder that if you need a synchrotron or cryoEM
for COVID work, you can put in rapid access proposals - details on
Diamond's website.
(I'll stop spamming the list now - thanks for your forebearance.)
Frank
On 02/04/2020 01:01, Nicholas Larsen wrote:
Hi Frank, I thought we were working quickly, but we only just got all
of your structures uploaded in our Proasis system today and can only
now begin analysis and design ideas. I don't know if we will have much
of anything by your deadline. Will there be additional design rounds?
Thanks again for making all this data available and it really is
inspirational what your team is doing to confront collaboratively this
global crisis.
Best,
Nick
On Wed, Apr 1, 2020 at 10:16 AM Frank von Delft
<frank.vonde...@sgc.ox.ac.uk <mailto:frank.vonde...@sgc.ox.ac.uk>> wrote:
All - last week's call for compound designs to the CoV-2 main
protease (https://covid.postera.ai/covid)
elicited an astonishing response... (I confess I was quite taken
aback.)
I just realised I should let this BB know the second call for
designs is now open. *Deadline is tomorrow 23:59 PST (April 2nd).
*(Apologies for those that weren't following on twitter.)*
*Two things:
* we're asking for designs especially focusing on covalent
inhibitors (read more here
<https://discuss.postera.ai/t/screening-cascade-fast-track-and-regular-track-of-designs/567>)
* the most convincing designs will be fast-tracked by spending
more money to cut several weeks off the testing (read more
here
<https://discuss.postera.ai/t/screening-cascade-fast-track-and-regular-track-of-designs/567>)
Happy designing!
Frank
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