As you say - HKL200 has a nomerge output.
Pointless/Aimless can read such outputs and sort out any indexing
alternatives, etc
You can specify that the spacegroup should not change.
(I presume this is not a major change? If your original SG is set to P1 and
the program detects 222 symmetry the I would reconsider my SG assognment!)

Cheers Eleanor

On Tue, 16 Jul 2019 at 04:29, 张士军 <[email protected]> wrote:

> Thanks all, I can merge them together with HKL2000 now, and I found it
> also can do "No merge original index" and merge different data sets with
> same unit cell by new version of HKL2000, which is better than old version
>
>
>
>
> -----Original Messages-----
> *From:*"Eleanor Dodson" <[email protected]>
> *Sent Time:*2019-07-15 22:08:01 (Monday)
> *To:* "张士军" <[email protected]>
> *Cc:* "[email protected]" <[email protected]>
> *Subject:* Re: [ccp4bb] muti-crystal averaging
>
> Do you mean these crystals have different unit cells? If so then DMMULTI
> is a useful technique..
>
> Or do you mean you have collected isomorphous data from several crystals
> and want to merge that data?
>
> In that case BLEND will help you decide how isomorhous the data sets are..
> Eleanor
>
> On Mon, 15 Jul 2019 at 13:12, 张士军 <[email protected]> wrote:
>
>> Dear all
>>
>> I want to average several sets of crystal data together, and I saw some
>> paper used DMMULTI program in CCP4, but I didn't find this program in
>> ccp4, but only find Blend in ccp4 which only used for unmerged reflection
>> files. I wondering is there any programs could use HKL2000 processed *.sca
>> file to do this. Thanks a lot!!!
>>
>> Best Regards
>>
>> Shijun
>>
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