https://www.nature.com/articles/449144a
Daniel A Bonsor PhD. Sundberg Lab Institute of Human Virology University of Maryland, Baltimore 725 W Lombard Street N370 Baltimore Maryland MD 21201 Tel: (410) 706-7457 From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of Zachary A. Wood Sent: Wednesday, April 10, 2019 10:30 AM To: CCP4BB@JISCMAIL.AC.UK Subject: [ccp4bb] A Max Perutz question Hello Fellow Structural Enthusiasts, My apologies for the slightly off-topic question. I am trying to track down a higher resolution image of the jpg that I have attached. I use this photo of Max Perutz when I am teaching about protein folding, and have always wanted a better quality one. I believe it is credited to Nature, and I am trying to find out what issue, but I am hoping that one of you may have more information or perhaps even a better photo. Thanks for any help, and for those of you who may never have seen this photo before, I hope you enjoy it. I like to imagine that Perutz is considering the challenges associated with folding that chain after he determined the crystal structure. If you have never read the discussion in his famous Nature paper, I will leave you with a relevant quote of him referring to the structural similarity between horse hemoglobin and sperm whale myoglobin, in which he predicts the thermodynamic hypothesis (Anfinsen’s dogma): “How does this arise? It is scarcely conceivable that a three-dimensional template forces the chain to take up this fold. More probably, the chain, once synthesized and provided with a haem group around which it can coil, takes up this configuration spontaneously, as the only one which satisfies the stereochemical requirements of its amino acid sequence.” Thank you for any help you may be able to offer! Best regards, Z *********************************************** Zachary A. Wood, Ph.D. Associate Professor and Graduate Coordinator Department of Biochemistry & Molecular Biology University of Georgia Life Sciences Building, Rm A426B 120 Green Street Athens, GA 30602-7229 Office: 706-583-0304 Lab: 706-583-0303 FAX: 706-542-1738 *********************************************** [cid:image001.jpg@01D4EF89.4B618FB0] ________________________________ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
