As part of our MRC-GCRF project we have two PhD positions to start in October 
2019 in the area of Neglected Tropical Diseases that affect approximately 
one-sixth of the world's population.  Further information on our network can be 
found at ntd.network.org


The first project led by Dr. Steven Cobb (s.l.c...@durham.ac.uk)


The development of new peptide and peptoid based treatments for Neglected 
Tropical Diseases (NTDs)

will adopt chemical and biological tools to elucidate the mode of action of 
peptides/peptoids that have peviously been identified as lead compounds. The 
successful candidate wil be trained in a range of chemical and biological 
techniques and while the project will be primarily based in Durham, certain 
aspects will be carried out during a placements with our partner in Rio de 
Janeiro.

The second project led by Dr. Ehmke Pohl (ehmke.p...@durham.ac.uk)

Discovering new drug targets in the Sphingolipid biosynthesis pathway of 
protozoan parasites

will focus on the characterisation of enzymes of the sphingolipid biosynthesis 
pathway as potential novel drug targets. The succesful candidates will employ a 
wide range of biochemical, biophysical and structural techniques ranging from 
X-ray crystallography to small angle X-ray scattering and if feasible cryo 
Electron Microsopy. While the project will be based in Durham, the work plan 
offers the opportunity of placements with our partners in India and/or Latin 
America.

Applicants will have a Master degree at 2:1 level or equivalent. The position 
is fully funded and open to UK, EU or international students. Applicants should 
send a CV (no more than 2 pages), a one-page summary why they are interested in 
this particular project as well as contact details of up to 3 references).


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