Dear Chandra,
A Million ways to die in the West (or when screening for HA derivatives).
But this has always worked for me:
https://www.cell.com/structure/fulltext/S0969-2126(00)00168-4
Just analyse ability to still form complex after modification.
Cheers,
Jesko

Am Mi., 2. Jan. 2019, 20:42 hat Chandramohan Kattamuri <
00001c5b7cb6c764-dmarc-requ...@jiscmail.ac.uk> geschrieben:

>
> Dear CCP4 members, Can someone suggest to me a methodology to covalently
> modify (non-cysteine) on component of a multicomponent complex with heavy
> atoms in order to achieve better phase determination?
>
> Thanks in advance
>
>
> Chandra
> kattamuricha...@yahoo.com
>
>
>
>
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