As part of the Newcastle-Liverpool-Durham BBSRC Doctoral Training Partnership (DTP) we have one competitive position on the interface between chemistry and biosciences on the development of new herbicides. The global demand for safe and sustainable food production is constantly rising due to global population growth coupled with the global success in fighting extreme poverty which in turn is leading to improved and changed diets. While global resources are limited, multiple herbicide resistance (MHR) in grass weeds, such as Black grass has emerged as a major threat to cereal production in the UK and beyond. Recently, the phi-class glutathionine transferase (GSTF1) has been identified as the key player of non-target site resistance in Black-grass. In order to unravel the molecular mechanism of MHR we have solved the high-resolution crystals structure of AmGSTF1 (Pohl group), and in parallel developed a series of specific ligands (Steel groups). These compounds possess significant potential as molecular probes and as herbicide additives.
Find more information about the DTP and the application process here: http://www.nld-dtp.org.uk/ Doctoral Training Partnership - Faculty of Medical Sciences<http://www.nld-dtp.org.uk/> www.nld-dtp.org.uk An exceptional programme led by three of the UK’s top Universities. Our partnership provides an opportunity for the next generation of young researchers to address outstanding scientific questions in the biosciences, this is an exceptional programme of research training which emphasises the interdisciplinary nature of modern biology. Contact me directly for more information (ehmke.p...@durham.ac.uk) ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
