A Postdoctoral position is available to work on a hot topic that links
meiotic recombination and DNA topology control. The project,
co-supervised by Profs Patrick Forterre and Claudine Mayer, aims to
unveil the molecular mechanisms of double-strand breaks catalyzed by
plant topoisomerase VI. The work will be performed in the team of
Jacques Oberto at I2BC (Orsay, France) and the laboratory of Pedro
Alzari at Institut Pasteur (Paris, France).
Various methods in structural biology(mainly X-ray crystallography but
also cyo-EM), combined with enzymology and biophysics will be used to
gain insights into the understanding of these fascinating nanomachines.
The candidate will benefit from a large and rich scientific environment
that extends to plant genetics as the project is part of an integrated
program that includes collaboration with the team of Mathilde Grelon
(INRA Versailles).
We seek a highly motivated candidate with a Ph.D. in the field of
structural biology and with strong experience in protein biochemistry
(production, purification and enzymatic assays). Experience in
macromolecular crystallography is a plus, but not a requirement.
Remuneration: according to salary scale and experience.The position is
open immediately and applications will be accepted until the position is
filled.
Send cover letter, CV and two references by e-mail to ma...@pasteur.fr
<mailto:ma...@pasteur.fr>and patrick.forte...@pasteur.fr
<mailto:patrick.forte...@pasteur.fr>
Selected publications related to the position:
Vrielynck N, Chambon A, Vezon D, Pereira L, Chelysheva L, De Muyt A,
Mézard C, Mayer C, Grelon M. A DNA topoisomerase VI-like complex
initiates meiotic recombination.
Science. 2016 Feb 26;351(6276):939-43. doi:10.1126/science.aad5196.
PubMed PMID: 26917763.
Gadelle D, Krupovic M, Raymann K, Mayer C, Forterre P. DNA topoisomerase
VIII: a novel subfamily of type IIB topoisomerases encoded by free or
integrated plasmids in Archaea and Bacteria.
Nucleic Acids Res. 2014 Jul;42(13):8578-91. doi: 10.1093/nar/gku568.
Epub 2014 Jul 2. PubMed PMID: 24990376.
Best wishes
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