We are seeking a postdoctoral fellow to join the Das laboratory in the Department of Chemistry, Purdue University, West Lafayette, IN, USA. Our lab investigates the structure and mechanism of action of bacterial effectors with an emphasis on deubiquitinating and ubiquitin ligating enzymes. These effectors are used by intracellular pathogens to manipulate host ubiquitin signaling, often employing radically different biochemical mechanism than observed in eukaryotic organisms. A striking example is the E1,E2-independent ubiquitination of host proteins by the SdeA ligase effector of Legionella pneumophila. See the following links to publications in this area:
1. http://www.pnas.org/content/112/49/15090.long<http://secure-web.cisco.com/10yKvKdhPcObD0HiNBZPiPZf20hKuVqFMeMEFKrKbS3UiQuEHG6EAqkTaQR9L2bmrw5AMCF0_xDNaujiXfwQPxjUFkW50Bowhj7M51NEPU_3T-Gq5Oc0QYUQUmiQqpetdIcs7dGJ-wsff5YQoWJ1M1T2gu1wXKb3BVMFMzRdF-DplWRp98Zpp0-aKzepz0YOQk4EV-R01AfaEz2VSu3YMbfbMo3dOCGWEY45BNOZWA20Kwh_9i0rTLHJSuP64-8VduN7_XG0s6XobSuUzwfJjI7T0-70fu_LuDoYD12SiNFclBfeOZImvuHdiG4hNSfJh87dCarvHqsGn2lK1TnUCW3-XUsLO3myNLePpz0SEKYs/http%3A%2F%2Fwww.pnas.org%2Fcontent%2F112%2F49%2F15090.long> 2. https://www.nature.com/articles/nature17657<https://secure-web.cisco.com/1wrv-sCmI5Pw8Iure4hzl34omVUbQy6hQSAxAYqCEN3Igjy0ea-IYDslYt6aAyZNtNf4Pydpp87hexGJOMD67o0LCzwBtHsc0yiJy1hI4gqra6xlLp2aBMjN47wNekbdaGTyU3sn9-_-7QOhZQZcAZ84XWFW1vW6wVxUdRrWGwKc25Y0t20mlkVcgPYQFfksEkP7v5CnuS6NHm7ZyyAznM3jzlR-soHTZUKmDiEwBOUfHmcd4kMtMc9Vgz73tVsJUk8P_4xypOu7Da3q5LqG8YcY3TNG9Bj46-8TRGe1QyY6pTl0AvRUty9K5WAobP6nKoL1bB3idp1piNiil-QhDMUNwXvtOSNu-nCQIEyfKZlU/https%3A%2F%2Fwww.nature.com%2Farticles%2Fnature17657> 3. http://pubs.acs.org/doi/abs/10.1021/acs.biochem.7b00664<http://secure-web.cisco.com/1LtrHq_Cl3cY09Gru4LnuPl0klouOuHGkN4618bgHuIyaPXR7dMbj5B2vOoBehg4zXJ80881Y1Qjr8RbDJHPBM3hk9YGTLDrZYumKaD8Lv1BKvlxF2XY4JzknSzo1Yg_D0GbMbuu2ZX6bSNNhqlS2WNMsTYFUKabhu8upNxs5jrpRw_Meb2pY6xUKk8eSwj4vKBjAF1fv7aOOOwwJJFAERbbMu-HfpU1JggqVftX-ay960d17xFMQn6pZp-4vfCPBQ2gEUdhzSwW-98TrOChAEd9ElqP8iz3IJoUt0zYGFV9sSoM20gcuQ8tNNikRqRu3ps3qB2I2D9h4k7h7EOLiZD05yrxjMblAyKqtw9Zi1F0/http%3A%2F%2Fpubs.acs.org%2Fdoi%2Fabs%2F10.1021%2Facs.biochem.7b00664> This position offers a significant opportunity to develop academic career of a really motivated Ph.D scholar through the provision of structural and mechanistic studies on a relatively novel group of enzymes. These studies are likely to provide interesting insights into how pathogens subjugate and subvert our post-translational machinery to establish infection. Applicants should hold a Ph.D. degree in relevant areas of chemistry, biochemistry, or biophysics as well as have significant experience in x-ray crystallography. If interested, please send your CV to c...@purdue.edu<mailto:c...@purdue.edu>. ? Best wishes for the holidays. Chitta Das Associate Professor of Chemistry Purdue University
