Hi, You can try the following using protein structures: 1) https://sbgrid.org/software/titles/quilt 2) Swiss PDBViewer, detect hydrophobic patches under Tool Surface 3) EBI PISA and look for negative delta G 4) look at protein-protein interaction and interface dbases Best, Debanu
> On Jul 26, 2017, at 10:05 AM, Hugh Morgan > <00001103e90ebb53-dmarc-requ...@jiscmail.ac.uk> wrote: > > Hi all, can anyone recommend a program for identifying hydrophobic > (aggregation) hotspots using either the amino acid sequence and/or structural > data. > Thanks in advance for your help > Hugh > > Ps. Have tried aggrescan but would like to try a few others and compare, > ideally a more structural based program.
