Dear all,
just a reminder that the deadline for applications is in one week.
Best regards,
Helgo
On 23 January 2017 at 15:36, Helgo Schmidt <
00000eb5ac628ee4-dmarc-requ...@jiscmail.ac.uk> wrote:
Dear all,
I’m looking for an enthusiastic and highly motivated PhD student to
join my newly established group at IGBMC, Strasbourg, France. We are
studying the structure and function of the dynein motor protein through an
integrated structural biology approach combining x-ray crystallography and
high-resolution cryoEM. The dynein motor is a complex and fascinating
molecular machine involved in essential cellular processes like mitosis,
organelle positioning and the beating of cilia (
https://www.ncbi.nlm.nih.gov/pubmed/24064538).
Applicants should possess a Master’s or Bachelor’s degree in the life
sciences, or a related discipline. The applicant should have experience in
molecular biology as well as protein expression and purification.
Experience in protein expression in yeast and/or insect cells would be
considered an advantage. Training in x-ray crystallography and cryoEM will
be provided. English language skills, the ability to work in a team,
initiative, flexibility as well as good organizational and learning skills
are required.
The IGBMC (http://www.igbmc.fr/) is one of the leading biomedical
research institutions in Europe and provides regular synchrotron access as
well as cutting-edge cryo-EM facilities like a Titan Krios electron
microscope equipped with a Cs corrector, a GIF energy filter, a phase plate
and a Gatan summit K2 direct electron detector. An ion beam scanning
electron microscope (cryo-FIB/SEM) and super-resolution fluorescence
microscopy for cellular tomography studies are also available.
Applicants should send a CV, a one-page summary of their research
experience and contact details for two referees till 31st of March to
helgoschmi...@gmail.com. The starting date is flexible.
Selected publications:
Schmidt H (2015) “Dynein motors: How AAA+ ring opening and closing
coordinates microtubule binding and linker movement.” Bioessays: 37:
532-543.
Schmidt H, Zalyte R, Urnavicius L, Carter AP (2015) “Structure of human
cytoplasmic dynein-2 primed for its power stroke.” Nature 518: 435-438.
Schmidt H, Gleave ES, Carter AP (2012) “Insights into dynein motor
domain function from a 3.3-Å crystal structure” Nat Struct Mol Biol.
19:492-7.
