Sure - crystallization selects what packs, which may constitute a very minor fraction of what you set up drops with. 1DUH is an example... -Luca
> On Apr 8, 2015, at 15:08, Sebastiaan Werten > <sebastiaan.wer...@uni-greifswald.de> wrote: > > Dear all, > > we are currently working on a protein that is known to exist in a > monomer-dimer equilibrium. At the high concentrations used for > crystallisation assays, the dimer is predominant and the monomer practically > undetectable. > > Nevertheless, one of the crystal forms that we have obtained contains the > monomeric species, not the dimer. > > I was wondering if anyone is aware of similar (published) cases, and if the > phenomenon as such has been discussed in detail anywhere? > > I did literature searches but so far couldn't find anything. > > Any pointers would be much appreciated! > > Best wishes, > > Sebastiaan Werten. >
