Dear all, An opportunity exists for a highly skilled and experienced Postdoctoral Scientist to join my lab in the Cell Signalling & Cell Death Division of the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia.
The laboratory is focused on the cellular signalling functions of a group of proteins related to protein kinases, called pseudokinases, which are believed to lack catalytic activity. The position is particularly interested in understanding their functions as molecular switches and how toggling these switches, whether by endogenous protein interactors or by small molecule modulators, regulates signalling pathways. We have a particular interest in the mechanism underlying activation of the pseudokinase, MLKL, which is a key mediator of cell death in the recently described necroptosis pathway (Murphy et al., Immunity 2013 39:443; Murphy et al., Biochem J 2014 457:369; Hildebrand et al., PNAS 2014 111:15072). Applicants should possess a doctorate (PhD), with experience in protein crystallography including crystallisation, data collection and structure determination. Additional experience with cell culture techniques, including flow cytometry, immunoprecipitation, immunoblot and/or insect cell expression is also preferred. This position is available for 2 years in the first instance. Salary is dependent on qualifications and experience. Up to 17% superannuation and attractive salary packaging options are available. Applications close on March 20, 2015. Please see http://www.wehi.edu.au/research-officer-murphy-laboratory for further details on the position and application process. Best wishes James Murphy -- James M. Murphy, PhD Cell Signalling and Cell Death Division Walter and Eliza Hall Institute of Medical Research 1G Royal Parade Parkville, VIC 3052, Australia http://www.wehi.edu.au/people/james-murphy Save the date: December 5-8, 2015, San Diego, CA. Kinases and pseudokinases: Spines, scaffolds and molecular switches http://www.asbmb.org/ASBMBMeetings/SpecialSymposia/Kinases/ ______________________________________________________________________ The information in this email is confidential and intended solely for the addressee. You must not disclose, forward, print or use it without the permission of the sender. ______________________________________________________________________
