Structural Biology of Molecular Targets from Neisseria A postdoctoral research associate position is available to pursue crystallographic studies of membrane protein targets from Neisseria in Prof. Alice Vrielink’s laboratory at the University of Western Australia, Perth. The position will involve expression and purification of target proteins followed by downstream crystallographic studies. A number of target enzymes are already in crystal form and studies are being directed towards inhibitor design. Other targets will also be pursued.
We are seeking applicants with a PhD in Biochemistry or a related discipline and with experience at macromolecular crystallography. A strong background in molecular biology, protein expression and purification of membrane proteins is also essential. The appointee will carry out research in the Vrielink laboratory but will also be part of a multidisciplinary team involving chemists and microbiologists with outstanding expertise at the study of Neisseria. As such this position offers excellent opportunities to interact across multiple disciplines and hence extend research expertise and career development. The Structural Biology Laboratory at the University of Western Australia has outstanding facilities for protein expression and purification as well as in-house X-ray facilities including a rotating anode generator and two MAR Imaging plate detectors. Crystallization and liquid handling robots are also available for crystallization experiments. The laboratory also houses state of the art protein facilities to study protein-protein and protein-ligand interactions include isothermal titration calorimetry, SEC-MALLS, and microscale thermophoresis. High resolution X-ray data collection will be carried out at the Australian Synchrotron. Perth is a thriving and vibrant city, which lies along the Indian Ocean and benefits from outstanding natural beauty and many opportunities for outdoor activities. Benefits include generous superannuation and salary packaging opportunities. Closing date: Friday 30 January 2015 Applications must be submitted online. Full details of the position's responsibilities and the selection criteria are outlined in the position description and applicants should clearly demonstrate they meet the selection criteria. Please see http://external.jobs.uwa.edu.au/cw/en/job/493825/research-associate-ref-493825 for further details and for information about applying. If you have any further questions about the position please contact me directly. Kind regards Alice Vrielink ****************************************************************************************************************** Alice Vrielink Professor of Structural Biology School of Chemistry and Biochemistry M310 University of Western Australia 35 Stirling Highway Crawley, WA, 6009 Australia Email: alice.vriel...@uwa.edu.au<mailto:alice.vriel...@uwa.edu.au> Phone: +61 08 6488 3162 Fax: +61 08 6488 1005 Webpage: http://crystal.bcs.uwa.edu.au/px/alice/ "We are what we repeatedly do. Excellence, then, is not an act, but a habit." Aristotle ******************************************************************************************************************
