Hi All, I have two derivative datasets (heavy atom A and B) and two native datasets (a and b), A and a are isomorphous, B and b are isomorphous, however, a and b (or A and B) are not isomorphous.
I was able to make two difference patterson maps (FA-Fa and FB-Fb) and search for heavy atoms against them, the possible positions of heavy atom A and B are very close to each other in the unit cell (which seems to me that I am very close to a right phase, though not there yet), I am wondering if there is any means for me to combine the information from FA-Fa and FB-Fb as the two native datasets are not isomorphous? And also, I have a homology model which I tried molecular replacement and failed, is there any means for me to combine the information from the model too? Best, Bei
