The following position is available at the University of Oklahoma. Please contact Liz Karr for any addition information.
A Postdoc position is available in microbiology and structural biology in the research group of Dr. Liz Karr in the Department of Microbiology and Plant Biology at the University of Oklahoma, Norman OK. The lab is part of an NIH COBRE in Structural Biology as well as a member of the Michael F. Price Institute for Structural Biology (ISB) housed in the Department of Chemistry and Biochemistry where there is an emphasis in anaerobic structural biology. Our group studies structure-function relationships of microbial transcription regulators. The postdoc will focus on studies of the novel methanogen specific transcription regulator, MsvR first identified by the Karr Lab. MsvR is a redox- sensitive transcription regulator that employs a number of cysteine residues to sense the redox environment in strict anaerobes. The project involves crystallization of MsvR and the MsvR/DNA complex and characterization of MsvR variants in vivo and in vitro. The lab utilizes a genetically tractable methanogen to study the in vivo role of MsvR in cell survival and to assess changes in the host transcriptome in msvR deletion strains. On a regular basis the postdoc will be involved in cloning, protein overexpression, site directed mutagenesis, anaerobic culturing and genetic manipulations as well as aerobic and anaerobic protein crystallization. We are looking for creative and motivated applicants with a strong background in molecular genetics and anaerobic microbiology and/or structural biology. The candidate must provide evidence of their research potential through publications and presentations, and activities involving mentoring and lab management are an asset. The initial appointment is for one year and is renewable upon satisfactory progress and continued funding. Salary level commensurate with experience. Equal opportunity, applications from under-represented groups are encouraged. Applications and informal inquiries should be sent to Liz Karr by email at lizkarr (at) ou (dot) edu. Applications should contain a letter describing your motivation and career goals, a CV highlighting your important contributions to research activities, and the contact details for three professional references. Applications will be accepted until the position is filled. Leonard M. Thomas Ph.D. Macromolecular Crystallography Laboratory Manager University of Oklahoma Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center 101 Stephenson Parkway Norman, OK 73019 405-325-1126 lmtho...@ou.edu http://barlywine.chem.ou.edu http://structuralbiology.ou.edu
