Dear Thomas There are several Ig-like domains that do not contain S-S bridges . I am not aware of a software tool that does what you'd like. However, two key papers on the Ig-like fold (old but still very relevant) that might be useful to you are:
(1) Bork, Holm & Sander - The Immunoglobulin Fold. Strcutural Classification, Sequence Patterns and Common Core - J.Mol.Biol (1994) 242, 309-320. (2) Harpaz & Chothia - Many of the Immunoglobulin Superfamily Domains in Cell Adhesion Molecules and Surface Receptors Belong to a New Structural Set Which is Close to That Containing Variable Domains - J. Mol. Biol. (1994), 238, 528-539. With best wishes Roberto On 9 Oct 2014, at 08:42, Thomas Krey <tk...@pasteur.fr> wrote: > Dear all, > > I was wondering, if there is a tool out there that allows the easy > classification of immunoglobulin and Ig-like domain subclasses based on a > given pdb file. As far as I am aware the state-of-the-art for immunoglobulin > domains is to determine the distance (in amino acids) between the two > cysteines forming the canonical disulfide bond between strands B and F. > However, I am facing a couple of Ig-like domains that do not contain this > disulfide bond ! > Any help will be highly appreciated. > > Best regards > Thomas > > Dr. Thomas Krey > Institut Pasteur > Structural Virology Unit > 25-28 Rue du Docteur Roux > 75015 Paris > France > tk...@pasteur.fr Roberto A. Steiner, PhD Randall Division of Cell and Molecular Biophysics Faculty of Life Sciences and Medicine King's College London roberto.stei...@kcl.ac.uk Phone 0044 20 78488216 Fax 0044 20 78486435 Room 3.10A New Hunt's House Guy's Campus SE1 1UL London
