A postdoc or staff scientist position is available immediately for a
computationally oriented crystallographer to join a project developing novel
methods for engineering improved protein solubility and crystallization. These
rational, sequence/structure-based methods have already been shown to work more
efficiently than previously published methods for improving crystallization via
mutagenesis. Ongoing work will focus on using structural, statistical, and
thermodynamic analyses to improve efficiency further and to extend the methods
to membrane proteins. While the focus of the project will be methods
development, validation will involve de novo crystal-structure determination
using proteins purified by the core lab of the Northeast Structural Genomics
Consortium (www.nesg.org), and there will be significant latitude in choosing
target proteins. A PhD in a related area is required as well as practical
experience in both software development and experimental crystal-structure
determination. Preference will be given to candidates who can start
immediately. An initial one-year appointment with a possibility of renewal
will include access to local housing in Manhattan subsidized by Columbia
University. Candidates should e-mail a CV and a list of three potential
referees to [email protected].
