A post-doctoral position is available at the laboratory of Chemistry and Biology of Metals (LCBM) in Grenoble (France). It is initially limited to 12 months but can be extended.
Lab description: The LCBM is a federation of cell biologists, protein chemists, synthetic chemists and spectrocopists developing their research in order to provide new insights into the unique question of the physiological function, the structure, the chemical reactivity and the regulation of complex biological systems transporting and utilizing metal ions. This is investigated through a great variety of experimental approaches combining molecular and cellular biology of both prokaryotes and eukaryotes, protein chemistry and enzymology, organic and inorganic synthetic chemistry and physico-chemical methods such as spectroscopy and theoretical chemistry. This research results in new concepts and applications in heavy metal toxicology and remediation, in bacterial pathogenicity and antibiotics, in neurodegenerative diseases, in catalysis and biocatalysis for selective transformations of organic compounds and for hydrogen production. Job description: Deciphering the biosynthetic pathway of NiFe-CO dehydrogenase, a key enzyme of the global carbon cycle in anaerobic microorganisms by time-resolved crystallography, EPR and Mossbauer spectroscopy. Protein multi-complexes will be studied in solution, using ITC andSAXS. Requirements: The candidate must have defended his (her) PhD in the last two years. Good expertise in biochemistry and related techniques applied to oxygen-sensitive metalloenzymes (protein purification under anaerobic conditions in glove box, spectroscopic characterization, ….) are required. Good expertise in protein crystallography. please, send your CV and two references to Christine Cavazza christine.cava...@cea.fr cavazzachrist...@gmail.com Dr Christine Cavazza Laboratoire de Chimie et Biologie des Métaux iRTSV, URM5249, CEA-Grenoble Bat k', 17 Rue des Martyrs, 38054 Grenoble Tel:00-33-4387891<tel:00-33-438789115>21
