I am grateful for all of the suggestions. I think I have enough tricks to try at this point, but I may check back with this group if things don't work out.
Many thanks once again, Chris On Sat, Jan 18, 2014 at 11:14 AM, Chris Fage <cdf...@gmail.com> wrote: > Hello Everyone, > > I am currently trying to phase a structure with an asymmetric unit > predicted to contain 20-24 monomers (space group P1). The native crystals, > while beautiful in appearance (see attached), only diffract to ~3.4-3.0 > angstroms at best, and SeMet-derived crystals grow with poor morphology > (small needles). Also, based a fluorescence scan, I know that mercury does > not bind appreciably. Other than screening for a new space group, what > options might I have for phasing this many monomers at lower resolution? Is > there any real chance of solving the structure in this space group? > > Thank you in advance for any suggestions! > > Regards, > Chris >
