*Postdoctoral position in structure-function studies of G-protein
networks in bacterial virulence and persistence*
*Structural Biology Brussels (Vrije Universiteit Brussel / VIB) --
Brussels, Belgium*
**
*At the Structural Biology Brussels laboratory (Vrije Universiteit
Brussel / VIB), we are looking for a highly*qualified and
motivated*postdoctoral researcher with a strong background in X-ray
crystallography and biophysics and interested in biochemical and
structural studies on enzymes and G-protein networks involved in
bacterial virulence and persistence**. *
**
*Project description: *
*Guanine nucleotide binding proteins (G-proteins or GTPases) are central
"regulatory hubs" in nearly all essential cellular processes. However,
the mechanisms of intra- and intermolecular regulation of complex
multi-domain GTPases and their involvement in human disease remain
largely unexplored. We aim to study the mechanism, regulation and
interaction networks of important representatives of these complex
GTPases, in the context of bacterial virulence and persistence. Through
collaboration with the group of Prof. J. Michiels (Centre of Microbial
and Plant Genetics, KULeuven) we will combine the genetics and biology
of persistence and virulence with detailed biochemical, biophysical and
structural /in vitro/ studies, in order to contribute to a complete
mechanistic understanding of the underlying principles at an atomic
level. *Different research topics in this field are currently being
started or ongoing in our lab and can be discussed in more detail with
the interested/selected candidate. For more information also see
www.verseeslab.structuralbiology.be.
**
*Required skills and experience:***
*·**Ph.D. in the field of structural biology *
*·**Experience in protein expression, purification and characterization*
*·**Experience in protein crystallization and structure determination by
X-ray crystallography*
*·**Knowledge in mechanistic enzymology and biophysical methods is an
asset *
*·**Good communication and teamwork skills*
**
*Contact:**Please send applications (including CV, research experience,
and at least two names and contact information for references) to:*
*Wim Versées, Structural Biology Brussels, Vrije Universiteit Brussel,
Pleinlaan 2, 1050 Brussel - **wim.vers...@vib-vub.be
<mailto:wim.vers...@vib-vub.be>**.*
**
*About Structural Biology Brussels: **VIB (the Flanders Institute for
Biotechnology) is an interdisciplinary non-profit research institute
based at 4 Flemish universities and employs a vibrant community of over
1000 life scientists. The Structural Biology Brussels lab focuses on the
functioning of proteins in all its aspects. Our multidisciplinary team
of about 80 researchers is housed in new laboratory facilities and
combines extensive expertise in structural biology (X-ray
crystallography, SAXS, NMR, EM and atomic force microscopy), biophysics,
enzymology and molecular biology.
*
With kind regards,
Wim
--
Prof. Dr. ir. Wim Versées
Structural Biology Brussels, Vrije Universiteit Brussel
VIB Structural Biology Research Center
Vrije Universiteit Brussel
Building E, room 4.2
Pleinlaan 2, 1050 Brussel, Belgium
****
