Dear all,
a structure I'm refining is enjoying a free R factor of 18 but still
suffers from mystery density that nothing in the crystallization
condition could explain. I can't explain it either. Maybe you like to
venture some guesses?
The missing ligand is derivatized benzoic acid, nitrobenzene or
benzamide. I didn't find anything obvious in the PDB. Any suggestions?
http://www.msf.bio.ic.ac.uk/images/puzzle/puzzle1.png
The second ligand is a longer shot, two blobs connected by a substantial
bridge. The two views are slightly rotated, and a bit of peptide is
shown to give an idea of the size.
http://www.msf.bio.ic.ac.uk/images/puzzle/puzzle2.png
http://www.msf.bio.ic.ac.uk/images/puzzle/puzzle3.png
Happy guessing!
Andreas
--
Andreas Förster
Crystallization and Xray Facility Manager
Centre for Structural Biology
Imperial College London
