The 47th Course of the International School of Crystallography: Structural Basis of Pharmacology: Deeper Understanding of Drug Discovery through Crystallography will be held in Erice (Italy) May 30 - June 8, 2014. More details are available below. An up-to-date program can be found in the School website at http://crystalerice.org/Erice2014/2014.htm.
Applications for the school are now open at http://erice2014.azuleon.org. Interested candidates should register by November 30th, 2013. We sincerely thank all the sponsors for their generous contribution to the conference. Sponsorship opportunities are available at http://crystalerice.org/Sponsor/sponsor_1.htm Giovanna Scapin for The 2014 Erice School Organizing Committee giovanna.sca...@merck.com<mailto:giovanna.sca...@merck.com> INTERNATIONAL SCHOOL OF CRYSTALLOGRAPHY 47th Course: STRUCTURAL BASIS OF PHARMACOLOGY: DEEPER UNDERSTANDING OF DRUG DISCOVERY THROUGH CRYSTALLOGRAPHY ERICE-SICILY: 30 MAY - 8 JUNE 2014 E. ARNOLD - R. PAUPTIT - V. SAMYGINA - R. STROUD DIRECTORS OF THE COURSE T.L. BLUNDELL DIRECTOR OF THE SCHOOL Sponsored by the: *International Union of Crystallography *International Union of Biochemistry and Molecular Biology *European Crystallographic Association *Italian Ministry of Education, University and Scientific Research *Sicilian Regional Government PURPOSE OF THE COURSE Diseases, from bacterial and viral infections to cancer to chronic maladies, are still among the greatest problems for mankind, in spite of tremendous progress in genetics, biology, and chemistry. Approaches to developing new treatments have changed over time, and so have the methodologies used, in order to solve the varied, new, challenging problems that may happen on the path to drug discovery. Together with ever-evolving experimental techniques, a variety of computational approaches have been applied at the various stages of the drug-design process, and in the past two decades structure-based drug design has become one of the mainstream approaches. This method can be used to target protein-ligand and protein-protein interactions and nowadays is applicable to all aspects of drug discovery, including lead identification, lead optimization, ADMET prediction, and drug repurposing. The purpose of the course is dual: 1) It will provide a review of the fundamentals and the application of crystallography to drug design, and an evaluation of the technology at the present state. 2) It will review the progress in this field and summarize the application and results to current fields of interest. In addition to lectures, there will be hands-on workshops providing training in using modern computer programs. CURRENT LIST OF SPEAKERS & TOPICS: T. Blundell : Targeting protein:protein interactions R. Pauptit : Drug design tales M. Congreve: Engineering GPCRs for drug design B. Kobilka: GPCR structures J. Blaney: Molecular Modeling and Drug Design A. Tramontano: Structural bioinformatics J.J. Irwin: Docking Experiences and expectations E. Arnold: Targeting resistance in design of anti-AIDS drugs S. Cusack: Targeting Influenza virus polymerase M. Rossmann: Virus Structures and antiviral drug design R. Stroud : Membrane protein structures C. Groom: The small molecule universe G. Klebe: Energetics of protein-ligand interactions S. Ventura: Protein Aggregation and Drug Design A. Podjarnj: High resolution protein ligand interactions by x-ray and neutron diffraction J. Wells: Turning on enzymes with small molecules H. Danielson: Enzymology and drug discovery V. Lamzin: Using ARP/WARP for structure-based drug design M. Hann: Molecular obesity and other addiction in drug discovery A. Lawson: Antibody technologies to stabilize targets for NCE screening G. Scapin: Structure-based drug design of drugs against diabetes C.-W. Chung: Drug design targeting bromodomains APPLICATIONS Interested candidates should register by November 30, 2013 using the form available at the URL http://erice2014.azuleon.org or write to the Executive Secretary of the International School of Crystallography: Dr. Annalisa Guerri Department of Chemistry University of Florence Tel: +39.055.4573429 Via della Lastruccia, 3 Fax: +39.055.4573437 50019 Sesto Fiorentino, Italy email: annalisa.gue...@unifi.it specifying: i) full name(s), age, gender, citizenship; ii) postal address, phone, fax, electronic mail; iii) present academic position and scientific interests; iv) the title or abstract of a scientific contribution to the poster session(s) which might be included in the programme. More information can be found at: http://www.crystalerice.org/Erice2014/2014.htm Notice: This e-mail message, together with any attachments, contains information of Merck & Co., Inc. (One Merck Drive, Whitehouse Station, New Jersey, USA 08889), and/or its affiliates Direct contact information for affiliates is available at http://www.merck.com/contact/contacts.html) that may be confidential, proprietary copyrighted and/or legally privileged. It is intended solely for the use of the individual or entity named on this message. If you are not the intended recipient, and have received this message in error, please notify us immediately by reply e-mail and then delete it from your system.
