Dear colleagues, please allow me to ask crystallography experts for advice in a bioinformatics issue:
Which methods (programs, servers) would you use and recommend to search computationally on the surface of a protein/protein complex (> 1100 aa) for concave and convex interaction sites with potential ligands of any kind (preferentially other proteins and peptides, but also nucleic acids or small metabolites and with emphasis on "potential", i.e. if no concrete ligand is known)? Thanks for any help from Karsten Niefind ------------------------------- Karsten Niefind University of Cologne Department of Chemistry Institute of Biochemistry Otto-Fischer-Str. 12-14 D-50674 Cologne Tel.: +49 221 470 6444 Fax: +49 221 470 3244
