I have successfully used modeller (standalone software; Sali lab) to generate multimeric complexes up to 24-mers
Hope tis helps From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of Sudipta Bhattacharyya Sent: Friday, 22 March 2013 5:00 a.m. To: CCP4BB@JISCMAIL.AC.UK Subject: [ccp4bb] homology modeling of dimeric proteins Dear All, Could annyone please suggest me any program or server that can build homology based models of dimeric/oligomeric proteins? Previously I have used many software/servers which can build the monomer of my target proteins but not the dimers. Self docking of homology based monomer is not working in my case since at certain domain one monomer is to some extent wrapped around the adjacent monomer in the template structure. I have also tried the project mode of SWISS-MODEL server but the program is not running with an error message of sequence misalignment; although I think the alignment is fine!!! Please suggest something that would be fruitful. Thanking you in advance for your kind cooperation. Regards, Sudipta Bhattacharyya, Department of Biochemistry and Molecular Biology, Colorado State University.
